MitoProteome

MitoProteome Database

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MitoProteome is an object-relational mitochondrial protein sequence database generated from experimental evidence and public databases, and containing both mitochondrial- and nuclear-encoded entries. The initial release contains 847 human mitochondrial proteins, 615 of which were experimentally determined by mass spectrometry(LC/MS/MS)(1).

Each protein is extensively annotated with data extracted from external databases, including:
  • Gene data extracted from LocusLink and Ensembl
  • Disease data extracted from OMIM
  • Interaction data extracted from MINT and DIP
  • Protein family data extracted from PFAM
  • Domain and Motif data extracted from InterPro
  • Fingerprint data extracted from PRINTS
  • BLAST hits extracted from NCBI NR
Literature References:

1) Steven W. Taylor, Eoin Fahy, Bing Zhang, Gary M. Glenn, Dale E. Warnock, Sandra Wiley, Anne N. Murphy, Sara P. Gaucher, Roderick A. Capaldi, Bradford W. Gibson, and Soumitra S. Ghosh. "Characterization of the human heart mitochondrial proteome." Nature Biotechnology March 2003 Volume 21 Number 3 pp 281 - 286. (Abstract) (Full Text)

2) Dawn Cotter, Purnima Guda, Eoin Fahy, Shankar Sumbramaniam. "MitoProteome: Mitochondrial Protein Sequence Database and Annotation System." Nucleic Acids Research 2004 32: D463-D467. (Abstract, Full Text)

Database Last Updated April 08, 2004


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