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MitoProteome Human Mitochondrial Protein Database
MitoProteome Database
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UniProt Annotations
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Related Proteins
MT000004
Gene Information
Entrez Gene ID
31
Gene Name
acetyl-CoA carboxylase alpha
Gene Symbol
ACACA
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID
Source
Type
Description
GO:0005829
ISS:UniProtKB
C
cytosol
GO:0070062
IDA:UniProt
C
extracellular vesicular exosome
GO:0005739
IEA:Ensembl
C
mitochondrion
GO:0003989
ISS:UniProtKB
F
acetyl-CoA carboxylase activity
GO:0005524
IEA:UniProtKB-KW
F
ATP binding
GO:0004075
IEA:UniProtKB-EC
F
biotin carboxylase activity
GO:0046872
IEA:UniProtKB-KW
F
metal ion binding
GO:0006084
ISS:UniProtKB
P
acetyl-CoA metabolic process
GO:0006768
TAS:Reactome
P
biotin metabolic process
GO:0006853
TAS:Reactome
P
carnitine shuttle
GO:0044255
TAS:Reactome
P
cellular lipid metabolic process
GO:0006112
TAS:Reactome
P
energy reserve metabolic process
GO:0006633
ISS:UniProtKB
P
fatty acid biosynthetic process
GO:0055088
IEA:Ensembl
P
lipid homeostasis
GO:0035338
TAS:Reactome
P
long-chain fatty-acyl-CoA biosynthetic process
GO:2001295
IEA:UniProtKB-UniPathway
P
malonyl-CoA biosynthetic process
GO:0044268
IEA:Ensembl
P
multicellular organismal protein metabolic process
GO:0031325
TAS:Reactome
P
positive regulation of cellular metabolic process
GO:0051289
ISS:UniProtKB
P
protein homotetramerization
GO:0044281
TAS:Reactome
P
small molecule metabolic process
GO:0001894
IEA:Ensembl
P
tissue homeostasis
GO:0019432
TAS:Reactome
P
triglyceride biosynthetic process
GO:0006766
TAS:Reactome
P
vitamin metabolic process
GO:0006767
TAS:Reactome
P
water-soluble vitamin metabolic process
KEGG Pathway Links
KEGG Pathway ID
Description
hsa04152
AMPK signaling pathway
ko04152
AMPK signaling pathway
hsa00061
Fatty acid biosynthesis
ko00061
Fatty acid biosynthesis
hsa_M00082
Fatty acid biosynthesis, initiation
M00082
Fatty acid biosynthesis, initiation
hsa01212
Fatty acid metabolism
ko01212
Fatty acid metabolism
hsa04910
Insulin signaling pathway
ko04910
Insulin signaling pathway
hsa01100
Metabolic pathways
hsa00640
Propanoate metabolism
ko00640
Propanoate metabolism
hsa00620
Pyruvate metabolism
ko00620
Pyruvate metabolism
BIOCYC Pathway Links
BIOCYC Pathway ID
Description
PWY0-1264
biotin-carboxyl carrier protein assembly
REACTOME Pathway Links
REACTOME Pathway ID
Description
REACT_147904
Activation of gene expression by SREBF (SREBP)
REACT_11153
Biotin transport and metabolism
REACT_2122
ChREBP activates metabolic gene expression
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403
Defective BTD causes biotidinase deficiency
REACT_169178
Defective CD320 causes methylmalonic aciduria
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415
Defective GIF causes intrinsic factor deficiency
REACT_169312
Defective HLCS causes multiple carboxylase deficiency
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313
Defective MUT causes methylmalonic aciduria mut type
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238
Defects in biotin (Btn) metabolism
REACT_169429
Defects in cobalamin (B12) metabolism
REACT_169385
Defects in vitamin and cofactor metabolism
REACT_116125
Disease
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism
REACT_1319
Fatty Acyl-CoA Biosynthesis
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix
REACT_1505
Integration of energy metabolism
REACT_111217
Metabolism
REACT_22258
Metabolism of lipids and lipoproteins
REACT_11193
Metabolism of vitamins and cofactors
REACT_11238
Metabolism of water-soluble vitamins and cofactors
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF)
REACT_1190
Triglyceride Biosynthesis
MitoProteome Human Mitochondrial Protein Database
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