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MT000013

UniProt Annotations

Entry Information

Gene Name	aconitase 1, soluble
Protein Entry	ACOC_HUMAN
UniProt ID	P21399
Species	Human

Comments

Comment type	Description
Catalytic Activity	Citrate = isocitrate.
Cofactor	Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269\|PubMed:16407072}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000269\|PubMed:16407072};
Function	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.
Function	Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269\|PubMed:1946430, ECO:0000269\|PubMed:8041788}.
Interaction	P20929:NEB; NbExp=2; IntAct=EBI-2847111, EBI-1049657; Q13326:SGCG; NbExp=2; IntAct=EBI-2847111, EBI-5357343;
Similarity	Belongs to the aconitase/IPM isomerase family. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210). {ECO:0000269\|PubMed:16407072, ECO:0000269\|PubMed:19762596, ECO:0000269\|PubMed:19762597, ECO:0000269\|PubMed:20053667}.
Web Resource	Name=Wikipedia; Note=Aconitase entry; URL="http://en.wikipedia.org/wiki/Aconitase";