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MT000017

UniProt Annotations

Entry Information

Gene Name	alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Entry	ADHX_HUMAN
UniProt ID	P11766
Species	Human

Comments

Comment type	Description
Catalytic Activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Catalytic Activity	S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H.
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269\|PubMed:3365377}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269\|PubMed:3365377};
Function	Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Miscellaneous	There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6.
Similarity	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Homodimer.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh5/";