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MT000019

Record overview

MITO IDMT000019
Gene ID204
SpeciesHomo sapiens (Human)
Gene Nameadenylate kinase 2
Gene SymbolAK2
SynonymsADK2; AK 2;
Alternate namesadenylate kinase 2, mitochondrial; AK2; AK 2; ATP:AMP phosphotransferase; ATP-AMP transphosphorylase 2; adenylate monophosphate kinase; adenylate kinase isoenzyme 2, mitochondrial;
Chromosome1
Map Location1p34
EC Number2.7.4.3
SummaryAdenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for AK2

Proteins

adenylate kinase 2, mitochondrial isoform a
Refseq ID:NP_001616
Protein GI:4502013
UniProt ID:P54819
mRNA ID:NM_001625
Length:239
RefSeq Status:
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDG
FPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEY
YRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
 
adenylate kinase 2, mitochondrial isoform b
Refseq ID:NP_037543
Protein GI:7524346
UniProt ID:P54819
mRNA ID:NM_013411
Length:232
RefSeq Status:
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDG
FPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEY
YRKRGIHSAIDASQTPDVVFASILAAFSKATS
 
adenylate kinase 2, mitochondrial isoform c
Refseq ID:NP_001186128
Protein GI:312836806
UniProt ID:P54819
mRNA ID:NM_001199199
Length:224
RefSeq Status:
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDG
FPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEYYRKRGIHS
AIDASQTPDVVFASILAAFSKATS