MitoProteome Database

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MT000022

Gene Information

Entrez Gene ID211
Gene Name5'-aminolevulinate synthase 1
Gene SymbolALAS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:HPACmitochondrion
GO:0005634 IDA:HPACnucleus
GO:0003870 IEA:UniProtKB-ECF5-aminolevulinate synthase activity
GO:0030170 IEA:InterProFpyridoxal phosphate binding
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006783 TAS:ReactomePheme biosynthetic process
GO:0006778 TAS:ReactomePporphyrin-containing compound metabolic process
GO:0006782 IEA:UniProtKB-UniPathwayPprotoporphyrinogen IX biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa00260Glycine, serine and threonine metabolism
ko00260Glycine, serine and threonine metabolism
hsa01100Metabolic pathways
hsa00860Porphyrin and chlorophyll metabolism
ko00860Porphyrin and chlorophyll metabolism
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-5920heme biosynthesis II
PWY-5920superpathway of heme biosynthesis from glycine
PWY-5189tetrapyrrole biosynthesis II
PWY-5189tetrapyrrole biosynthesis II (from glycine)
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_9465Heme biosynthesis
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_9431Metabolism of porphyrins
REACT_200788Mitochondrial biogenesis
REACT_200751Organelle biogenesis and maintenance
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_200608Transcriptional activation of mitochondrial biogenesis