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MT000024

UniProt Annotations

Entry Information

Gene Name	albumin
Protein Entry	ALBU_HUMAN
UniProt ID	P02768
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P02768-1; Sequence=Displayed; Name=2; IsoId=P02768-2; Sequence=VSP_021275;
Caution	A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed neurotensin- related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and blood flow. {ECO:0000305}.
Disease	Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269\|PubMed:7852505, ECO:0000269\|PubMed:8048949, ECO:0000269\|PubMed:9329347, ECO:0000269\|PubMed:9589637}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. {ECO:0000269\|PubMed:19021548}.
Interaction	P02786:TFRC; NbExp=2; IntAct=EBI-714423, EBI-355727;
Polymorphism	A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.
Ptm	Acetylated on Lys-223 by acetylsalicylic acid.
Ptm	Glycated in diabetic patients.
Ptm	Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys- 606.
Ptm	Phosphorylation sites are present in the extracellular medium. {ECO:0000269\|PubMed:18318008, ECO:0000269\|PubMed:19690332}.
Sequence Caution	Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the ALB/AFP/VDB family. {ECO:0000255\|PROSITE-ProRule:PRU00769}.
Similarity	Contains 3 albumin domains. {ECO:0000255\|PROSITE- ProRule:PRU00769}.
Subcellular Location	Secreted.
Tissue Specificity	Plasma.
Web Resource	Name=Albumin Website; URL="http://www.albumin.org";
Web Resource	Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alb/";
Web Resource	Name=Wikipedia; Note=Serum albumin entry; URL="http://en.wikipedia.org/wiki/Serum_albumin";