MitoProteome Database

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MT000030

UniProt Annotations

Entry Information

Gene Name	ATP-binding cassette, sub-family D (ALD), member 2
Protein Entry	ABCD2_HUMAN
UniProt ID	Q9UBJ2
Species	Human

Comments

Comment type	Description
Function	Probable transporter.
Similarity	Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. {ECO:0000305}.
Similarity	Contains 1 ABC transmembrane type-1 domain. {ECO:0000255\|PROSITE-ProRule:PRU00441}.
Similarity	Contains 1 ABC transporter domain. {ECO:0000255\|PROSITE-ProRule:PRU00434}.
Subcellular Location	Peroxisome membrane; Multi-pass membrane protein.
Subunit	Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19. {ECO:0000269\|PubMed:10551832, ECO:0000269\|PubMed:10704444, ECO:0000269\|PubMed:10777694}.
Tissue Specificity	Predominantly expressed in brain and heart.
Web Resource	Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q9UBJ2";