MitoProteome Database

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MT000032

Gene Information

Entrez Gene ID239
Gene Namearachidonate 12-lipoxygenase
Gene SymbolALOX12
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0070062 IDA:UniProtCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0042383 IDA:UniProtKBCsarcolemma
GO:0004052 IDA:UniProtKBFarachidonate 12-lipoxygenase activity
GO:0051120 TAS:ReactomeFhepoxilin A3 synthase activity
GO:0047977 ISS:UniProtKBFhepoxilin-epoxide hydrolase activity
GO:0005506 IEA:InterProFiron ion binding
GO:0016165 IDA:UniProtKBFlinoleate 13S-lipoxygenase activity
GO:0016702 TAS:ReactomeFoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0007568 IEA:EnsemblPaging
GO:0019369 IDA:UniProtKBParachidonic acid metabolic process
GO:0006928 IMP:UniProtKBPcellular component movement
GO:0071396 IEA:EnsemblPcellular response to lipid
GO:0061436 ISS:UniProtKBPestablishment of skin barrier
GO:0019395 IMP:UniProtKBPfatty acid oxidation
GO:0051122 ISS:UniProtKBPhepoxilin biosynthetic process
GO:0051121 TAS:ReactomePhepoxilin metabolic process
GO:1901751 IDA:UniProtKBPleukotriene A4 metabolic process
GO:0043651 IDA:UniProtKBPlinoleic acid metabolic process
GO:2001303 IDA:UniProtKBPlipoxin A4 biosynthetic process
GO:2001306 IDA:UniProtKBPlipoxin B4 biosynthetic process
GO:2001300 TAS:ReactomePlipoxin metabolic process
GO:0019372 IDA:UniProtKBPlipoxygenase pathway
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0010656 IMP:UniProtKBPnegative regulation of muscle cell apoptotic process
GO:0090331 ISS:UniProtKBPnegative regulation of platelet aggregation
GO:0045766 IMP:UniProtKBPpositive regulation of angiogenesis
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0045785 IMP:UniProtKBPpositive regulation of cell adhesion
GO:0030307 IMP:UniProtKBPpositive regulation of cell growth
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0043280 IEA:EnsemblPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045603 IEA:EnsemblPpositive regulation of endothelial cell differentiation
GO:0010595 IEA:EnsemblPpositive regulation of endothelial cell migration
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0051901 IEA:EnsemblPpositive regulation of mitochondrial depolarization
GO:0048661 IEA:EnsemblPpositive regulation of smooth muscle cell proliferation
GO:0045909 IEA:EnsemblPpositive regulation of vasodilation
GO:0072593 NAS:UniProtKBPreactive oxygen species metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0042554 NAS:UniProtKBPsuperoxide anion generation
KEGG Pathway Links
KEGG Pathway IDDescription
hsa00590Arachidonic acid metabolism
ko00590Arachidonic acid metabolism
hsa04750Inflammatory mediator regulation of TRP channels
ko04750Inflammatory mediator regulation of TRP channels
hsa01100Metabolic pathways
hsa04726Serotonergic synapse
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY66-392lipoxin biosynthesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_147851Arachidonic acid metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_150201Synthesis of 12-eicosatetraenoic acid derivatives
REACT_150292Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
REACT_150320Synthesis of Lipoxins (LX)