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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000037
UniProt Annotations
Entry Information
Gene Name
annexin A1
Protein Entry
ANXA1_HUMAN
UniProt ID
P04083
Species
Human
Comments
Comment type
Description
Domain
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Interaction
Q9Y6K9:IKBKG; NbExp=6; IntAct=EBI-354007, EBI-81279; Q13546:RIPK1; NbExp=5; IntAct=EBI-354007, EBI-358507;
Ptm
Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity. {ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:2457390}.
Similarity
Belongs to the annexin family. {ECO:0000305}.
Similarity
Contains 4 annexin repeats. {ECO:0000305}.
Subcellular Location
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.
Subunit
Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity). {ECO:0000250}.
Web Resource
Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ANXA1ID653ch9q21.html";
MitoProteome Human Mitochondrial Protein Database
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