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MT000041

UniProt Annotations

Entry Information

Gene Name	arginase 2
Protein Entry	ARGI2_HUMAN
UniProt ID	P78540
Species	Human

Comments

Comment type	Description
Catalytic Activity	L-arginine + H(2)O = L-ornithine + urea.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255\|PROSITE-ProRule:PRU00742, ECO:0000269\|PubMed:12859189}; Note=Binds 2 manganese ions per subunit. {ECO:0000255\|PROSITE- ProRule:PRU00742, ECO:0000269\|PubMed:12859189};
Function	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. {ECO:0000269\|PubMed:12859189}.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Similarity	Belongs to the arginase family. {ECO:0000255\|PROSITE- ProRule:PRU00742}.
Subcellular Location	Mitochondrion.
Subunit	Homotrimer. {ECO:0000269\|PubMed:12859189}.
Tissue Specificity	Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.
Web Resource	Name=Wikipedia; Note=Arginase entry; URL="http://en.wikipedia.org/wiki/Arginase";