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MT000042

UniProt Annotations

Entry Information

Gene Name	ADP-ribosylation factor-like 2
Protein Entry	ARL2_HUMAN
UniProt ID	P36404
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P36404-1; Sequence=Displayed; Name=2; IsoId=P36404-2; Sequence=VSP_047278;
Function	Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. {ECO:0000269\|PubMed:10831612, ECO:0000269\|PubMed:16525022, ECO:0000269\|PubMed:18234692, ECO:0000269\|PubMed:18588884, ECO:0000269\|PubMed:20740604}.
Interaction	O43924:PDE6D; NbExp=4; IntAct=EBI-752365, EBI-712685; Q13432:UNC119; NbExp=2; IntAct=EBI-752365, EBI-711260;
Ptm	Not N-myristoylated.
Similarity	Belongs to the small GTPase superfamily. Arf family. {ECO:0000305}.
Subcellular Location	Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250}.
Subunit	Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119. {ECO:0000269\|PubMed:10488091, ECO:0000269\|PubMed:10831612, ECO:0000269\|PubMed:11303027, ECO:0000269\|PubMed:11847227, ECO:0000269\|PubMed:17452337, ECO:0000269\|PubMed:18234692, ECO:0000269\|PubMed:18981177, ECO:0000269\|PubMed:19368893}.