MitoProteome Database

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MT000043

Gene Information

Entrez Gene ID409
Gene Namearrestin, beta 2
Gene SymbolARRB2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016323 IEA:EnsemblCbasolateral plasma membrane
GO:0005905 IEA:UniProtKB-KWCcoated pit
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0031410 IDA:UniProtKBCcytoplasmic vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 IEA:EnsemblCdendritic spine
GO:0030139 IDA:UniProtKBCendocytic vesicle
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0014069 IEA:EnsemblCpostsynaptic density
GO:0045211 IEA:EnsemblCpostsynaptic membrane
GO:0031701 IPI:UniProtKBFangiotensin receptor binding
GO:0019899 IPI:UniProtFenzyme binding
GO:0001664 IPI:UniProtKBFG-protein coupled receptor binding
GO:0032947 IDA:BHF-UCLFprotein complex scaffold
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0007628 IEA:EnsemblPadult walking behavior
GO:0006309 IEA:EnsemblPapoptotic DNA fragmentation
GO:0007596 TAS:ReactomePblood coagulation
GO:0007420 IEA:EnsemblPbrain development
GO:0060326 IMP:UniProtKBPcell chemotaxis
GO:0002032 IMP:UniProtKBPdesensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0050965 IEA:EnsemblPdetection of temperature stimulus involved in sensory perception of pain
GO:0042699 IEA:EnsemblPfollicle-stimulating hormone signaling pathway
GO:0002031 IDA:UniProtKBPG-protein coupled receptor internalization
GO:0034260 IEA:EnsemblPnegative regulation of GTPase activity
GO:0032695 IEA:EnsemblPnegative regulation of interleukin-12 production
GO:0032691 IEA:EnsemblPnegative regulation of interleukin-1 beta production
GO:0032715 IEA:EnsemblPnegative regulation of interleukin-6 production
GO:0045953 IMP:UniProtKBPnegative regulation of natural killer cell mediated cytotoxicity
GO:0032088 IDA:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0031397 IDA:UniProtKBPnegative regulation of protein ubiquitination
GO:0034392 IEA:EnsemblPnegative regulation of smooth muscle cell apoptotic process
GO:0034122 IEA:EnsemblPnegative regulation of toll-like receptor signaling pathway
GO:0032720 IEA:EnsemblPnegative regulation of tumor necrosis factor production
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0030168 TAS:ReactomePplatelet activation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0051928 IEA:EnsemblPpositive regulation of calcium ion transport
GO:2000573 IEA:EnsemblPpositive regulation of DNA biosynthetic process
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0050731 IEA:EnsemblPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 IEA:EnsemblPpositive regulation of protein kinase B signaling
GO:0031398 IGI:BHF-UCLPpositive regulation of protein ubiquitination
GO:0002092 IMP:UniProtKBPpositive regulation of receptor internalization
GO:0090200 IEA:EnsemblPpositive regulation of release of cytochrome c from mitochondria
GO:0032226 IEA:EnsemblPpositive regulation of synaptic transmission, dopaminergic
GO:0043161 IMP:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0015031 IEA:UniProtKB-KWPprotein transport
GO:0016567 IMP:UniProtKBPprotein ubiquitination
GO:0031623 IDA:BHF-UCLPreceptor internalization
GO:0060765 IDA:BHF-UCLPregulation of androgen receptor signaling pathway
GO:0006366 IDA:UniProtKBPtranscription from RNA polymerase II promoter
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04062Chemokine signaling pathway
ko04062Chemokine signaling pathway
hsa04728Dopaminergic synapse
ko04728Dopaminergic synapse
hsa04144Endocytosis
ko04144Endocytosis
hsa04010MAPK signaling pathway
ko04010MAPK signaling pathway
hsa05032Morphine addiction
ko05032Morphine addiction
hsa04740Olfactory transduction
ko04740Olfactory transduction
hsa04744Phototransduction
ko04744Phototransduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_172694beta-catenin independent WNT signaling
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_604Hemostasis
REACT_172581PCP/CE pathway
REACT_798Platelet activation, signaling and aggregation
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_172599WNT5A-dependent internalization of FZD4