MitoProteome Database

MT000045

Gene Information

Entrez Gene ID	445
Gene Name	argininosuccinate synthase 1
Gene Symbol	ASS1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070852	IEA:Ensembl	C	cell body fiber
GO:0005737	TAS:ProtInc	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005783	IEA:Ensembl	C	endoplasmic reticulum
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005764	IEA:Ensembl	C	lysosome
GO:0005741	IEA:Ensembl	C	mitochondrial outer membrane
GO:0005634	IEA:Ensembl	C	nucleus
GO:0043204	IEA:Ensembl	C	perikaryon
GO:0016597	IMP:BHF-UCL	F	amino acid binding
GO:0004055	IMP:BHF-UCL	F	argininosuccinate synthase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0044822	IDA:UniProtKB	F	poly(A) RNA binding
GO:0015643	IEA:Ensembl	F	toxic substance binding
GO:0006953	IEA:Ensembl	P	acute-phase response
GO:0007568	IEA:Ensembl	P	aging
GO:0006526	IEA:UniProtKB-UniPathway	P	arginine biosynthetic process
GO:0000053	IMP:BHF-UCL	P	argininosuccinate metabolic process
GO:0006531	IMP:BHF-UCL	P	aspartate metabolic process
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0071418	IEA:Ensembl	P	cellular response to amine stimulus
GO:0071230	IEA:Ensembl	P	cellular response to amino acid stimulus
GO:0071242	IEA:Ensembl	P	cellular response to ammonium ion
GO:0071320	IEA:Ensembl	P	cellular response to cAMP
GO:0071549	IEA:Ensembl	P	cellular response to dexamethasone stimulus
GO:0071377	IEA:Ensembl	P	cellular response to glucagon stimulus
GO:0071346	IEA:Ensembl	P	cellular response to interferon-gamma
GO:0071499	IMP:BHF-UCL	P	cellular response to laminar fluid shear stress
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0071400	IEA:Ensembl	P	cellular response to oleic acid
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0000052	IMP:BHF-UCL	P	citrulline metabolic process
GO:0060539	IEA:Ensembl	P	diaphragm development
GO:0001822	IEA:Ensembl	P	kidney development
GO:0001889	IEA:Ensembl	P	liver development
GO:0007494	IEA:Ensembl	P	midgut development
GO:1903038	IMP:BHF-UCL	P	negative regulation of leukocyte cell-cell adhesion
GO:0045429	IMP:BHF-UCL	P	positive regulation of nitric oxide biosynthetic process
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0060416	IEA:Ensembl	P	response to growth hormone
GO:0010046	IEA:Ensembl	P	response to mycotoxin
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0000050	IMP:BHF-UCL	P	urea cycle

KEGG Pathway Links

KEGG Pathway ID	Description
hsa00250	Alanine, aspartate and glutamate metabolism
ko00250	Alanine, aspartate and glutamate metabolism
hsa00330	Arginine and proline metabolism
ko00330	Arginine and proline metabolism
hsa01230	Biosynthesis of amino acids
ko01230	Biosynthesis of amino acids
hsa01100	Metabolic pathways
hsa_M00029	Urea cycle
M00029	Urea cycle

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
ARGININE-SYN4-PWY	arginine biosynthesis IV
PWY-4983	citrulline-nitric oxide cycle
PWY-4983	citrulline-nitric oxide cycle
PWY-5004	superpathway of citrulline metabolism
PWY-5004	superpathway of citrulline metabolism
PWY-4984	urea cycle
PWY-4984	urea cycle

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_847	Urea cycle