MitoProteome Database

MT000060

Record overview

MITO ID	MT000060
Gene ID	522
Species	Homo sapiens (Human)
Gene Name	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
Gene Symbol	ATP5J
Synonyms	F6; CF6; ATP5; ATPM; ATP5A;
Alternate names	ATP synthase-coupling factor 6, mitochondrial; ATPase subunit F6; coupling factor 6; proliferation-inducing protein 36; mitochondrial ATP synthase, subunit F6; mitochondrial ATPase coupling factor 6; mitochondrial ATP synthase, coupling factor 6; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6;
Chromosome	21
Map Location	21q21.1
Summary	Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex, required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. A pseudogene exists on chromosome Yp11.[provided by RefSeq, Jun 2010]
Orthologs	View orthologs and multiple alignments for ATP5J

Proteins

ATP synthase-coupling factor 6, mitochondrial isoform a precursor

Refseq ID:	NP_001676
Protein GI:	18644883
UniProt ID:	P18859
mRNA ID:	NM_001685
Length:	108
RefSeq Status:

`MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAFNKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKF EVIEKPQA`

N
transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

ATP synthase-coupling factor 6, mitochondrial isoform a precursor

Refseq ID:	NP_001003703
Protein GI:	51479143
UniProt ID:	P18859
mRNA ID:	NM_001003703
Length:	108
RefSeq Status:

Protein sequence is identical to GI:18644883 (mRNA isoform)

N
transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

ATP synthase-coupling factor 6, mitochondrial isoform a precursor

Refseq ID:	NP_001003696
Protein GI:	51479137
UniProt ID:	P18859
mRNA ID:	NM_001003696
Length:	108
RefSeq Status:

Protein sequence is identical to GI:18644883 (mRNA isoform)

N
transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

ATP synthase-coupling factor 6, mitochondrial isoform a precursor

Refseq ID:	NP_001003697
Protein GI:	51479139
UniProt ID:	P18859
mRNA ID:	NM_001003697
Length:	108
RefSeq Status:

Protein sequence is identical to GI:18644883 (mRNA isoform)

N
transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

ATP synthase-coupling factor 6, mitochondrial isoform b precursor

Refseq ID:	NP_001003701
Protein GI:	51479141
UniProt ID:	P18859
mRNA ID:	NM_001003701
Length:	116
RefSeq Status:

`MHCDGGISMILQRLFRFSSVIRSAVSVHLRRNIGVTAVAFNKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPT FKFEDPKFEVIEKPQA`

N
transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA

transit_peptide: 1..32
calculated_mol_wt: 3645
peptide sequence: 
MILQRLFRFSSVIRSAVSVHLRRNIGVTAVAF

mat_peptide: 33..108
product: ATP synthase-coupling factor 6, mitochondrial isoform a
calculated_mol_wt: 8960
peptide sequence: 
NKELDPIQKLFVDKIREYKSKRQTSGGPVDASSEYQQELERELFKLKQMFGNADMNTFPTFKFEDPKFEVIEKPQA