MitoProteome Database

MT000063

Gene Information

Entrez Gene ID	538
Gene Name	ATPase, Cu++ transporting, alpha polypeptide
Gene Symbol	ATP7A
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016323	IDA:UniProtKB	C	basolateral plasma membrane
GO:0031526	IEA:Ensembl	C	brush border membrane
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005794	IDA:UniProtKB	C	Golgi apparatus
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005770	IDA:UniProtKB	C	late endosome
GO:0016020	IDA:UniProtKB	C	membrane
GO:0043025	ISS:UniProtKB	C	neuronal cell body
GO:0043005	ISS:UniProtKB	C	neuron projection
GO:0048471	IDA:UniProtKB	C	perinuclear region of cytoplasm
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0030141	IEA:Ensembl	C	secretory granule
GO:0005802	IDA:UniProtKB	C	trans-Golgi network
GO:0030140	IMP:HGNC	C	trans-Golgi network transport vesicle
GO:0005524	TAS:HGNC	F	ATP binding
GO:0032767	IPI:UniProtKB	F	copper-dependent protein binding
GO:0004008	ISS:UniProtKB	F	copper-exporting ATPase activity
GO:0005507	IDA:UniProtKB	F	copper ion binding
GO:0005375	ISS:UniProtKB	F	copper ion transmembrane transporter activity
GO:0016532	ISS:UniProtKB	F	superoxide dismutase copper chaperone activity
GO:0001568	ISS:UniProtKB	P	blood vessel development
GO:0001974	ISS:UniProtKB	P	blood vessel remodeling
GO:0051216	ISS:UniProtKB	P	cartilage development
GO:0006584	ISS:UniProtKB	P	catecholamine metabolic process
GO:0006878	IMP:UniProtKB	P	cellular copper ion homeostasis
GO:0021954	ISS:UniProtKB	P	central nervous system neuron development
GO:0021702	ISS:UniProtKB	P	cerebellar Purkinje cell differentiation
GO:0030199	ISS:UniProtKB	P	collagen fibril organization
GO:0060003	ISS:UniProtKB	P	copper ion export
GO:0015677	ISS:UniProtKB	P	copper ion import
GO:0006825	IMP:UniProtKB	P	copper ion transport
GO:0048813	IEA:Ensembl	P	dendrite morphogenesis
GO:0010273	ISS:UniProtKB	P	detoxification of copper ion
GO:0042417	ISS:UniProtKB	P	dopamine metabolic process
GO:0048251	ISS:UniProtKB	P	elastic fiber assembly
GO:0051542	ISS:UniProtKB	P	elastin biosynthetic process
GO:0042414	ISS:UniProtKB	P	epinephrine metabolic process
GO:0030198	ISS:UniProtKB	P	extracellular matrix organization
GO:0031069	ISS:UniProtKB	P	hair follicle morphogenesis
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0034220	TAS:Reactome	P	ion transmembrane transport
GO:0007595	IEA:Ensembl	P	lactation
GO:0007626	ISS:UniProtKB	P	locomotory behavior
GO:0048286	ISS:UniProtKB	P	lung alveolus development
GO:0007005	ISS:UniProtKB	P	mitochondrion organization
GO:0048553	ISS:UniProtKB	P	negative regulation of metalloenzyme activity
GO:0043524	IEA:Ensembl	P	negative regulation of neuron apoptotic process
GO:0048812	ISS:UniProtKB	P	neuron projection morphogenesis
GO:0042421	IEA:Ensembl	P	norepinephrine biosynthetic process
GO:0042415	ISS:UniProtKB	P	norepinephrine metabolic process
GO:0018205	ISS:UniProtKB	P	peptidyl-lysine modification
GO:0043473	ISS:UniProtKB	P	pigmentation
GO:0043085	ISS:UniProtKB	P	positive regulation of catalytic activity
GO:0048554	ISS:UniProtKB	P	positive regulation of metalloenzyme activity
GO:0051353	IDA:UniProtKB	P	positive regulation of oxidoreductase activity
GO:0021860	ISS:UniProtKB	P	pyramidal neuron development
GO:0010468	IEA:Ensembl	P	regulation of gene expression
GO:0002082	ISS:UniProtKB	P	regulation of oxidative phosphorylation
GO:0001836	IEA:Ensembl	P	release of cytochrome c from mitochondria
GO:0019430	ISS:UniProtKB	P	removal of superoxide radicals
GO:0010041	IEA:Ensembl	P	response to iron(III) ion
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0042428	ISS:UniProtKB	P	serotonin metabolic process
GO:0043588	ISS:UniProtKB	P	skin development
GO:0042093	ISS:UniProtKB	P	T-helper cell differentiation
GO:0055085	TAS:Reactome	P	transmembrane transport
GO:0006568	ISS:UniProtKB	P	tryptophan metabolic process
GO:0006570	IEA:Ensembl	P	tyrosine metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04978	Mineral absorption
ko04978	Mineral absorption

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_120956	Cellular responses to stress
REACT_172715	Detoxification of Reactive Oxygen Species
REACT_25300	Ion channel transport
REACT_25149	Ion transport by P-type ATPases
REACT_15518	Transmembrane transport of small molecules