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MT000071

Record overview

MITO ID	MT000071
Gene ID	581
Species	Homo sapiens (Human)
Gene Name	BCL2-associated X protein
Gene Symbol	BAX
Synonyms	BCL2L4;
Alternate names	apoptosis regulator BAX; bcl2-L-4; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega; bcl-2-like protein 4; BCL2-associated X protein omega;
Chromosome	19
Map Location	19q13.3-q13.4
Summary	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for BAX

Proteins

apoptosis regulator BAX gamma

Refseq ID:	NP_001278358
Protein GI:	612149801
UniProt ID:	Q5ZPJ0
mRNA ID:	NM_001291429
Length:	181
RefSeq Status:

apoptosis regulator BAX isoform 1
`MGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIM GWTLDFLRERLLGWIQDQGGWVRLLKPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCPLPIFRSSDVVYNAFSLRV`

Refseq ID:	NP_001278357
Protein GI:	612149787
UniProt ID:	Q07812
mRNA ID:	NM_001291428
Length:	221
RefSeq Status:

apoptosis regulator BAX isoform alpha
`MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMF SDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWGLPLAESLKRLMSLSPGRPPLLLWDAHVADRDHLCGGSAHRL THHLEEDGLRPPAALDCVFPP`

Refseq ID:	NP_620116
Protein GI:	20631958
UniProt ID:	Q07812
mRNA ID:	NM_138761
Length:	192
RefSeq Status:

apoptosis regulator BAX isoform beta
`MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMF SDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG`

Refseq ID:	NP_004315
Protein GI:	4757838
UniProt ID:	Q07812
mRNA ID:	NM_004324
Length:	218
RefSeq Status:

apoptosis regulator BAX isoform delta
`MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMF SDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWVRLLKPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCP LPIFRSSDVVYNAFSLRV`

Refseq ID:	NP_620118
Protein GI:	20631964
UniProt ID:	Q07812
mRNA ID:	NM_138763
Length:	143
RefSeq Status:

apoptosis regulator BAX isoform lambda
`MDGSGEQPRGGGPTSSEQIMKTGALLLQGMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLL GWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG`

Refseq ID:	NP_001278359
Protein GI:	612149804
UniProt ID:	Q5ZPJ1
mRNA ID:	NM_001291430
Length:	140
RefSeq Status:

apoptosis regulator BAX isoform sigma
`MIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWVRLLKPPHPHHRALTTAPAP PSLPPATPLGPWAFWSRSQWCPLPIFRSSDVVYNAFSLRV`

Refseq ID:	NP_620119
Protein GI:	242117893
UniProt ID:	Q07812
mRNA ID:	NM_138764
Length:	179
RefSeq Status:

apoptosis regulator BAX isoform zeta
`MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMF SDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWTVTIFVAGVLTASLTIWKKMG`

Refseq ID:	NP_001278360
Protein GI:	612149806
UniProt ID:	Q07812
mRNA ID:	NM_001291431
Length:	114
RefSeq Status:

`MIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVA GVLTASLTIWKKMG`