MitoProteome Database

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MT000072

UniProt Annotations

Entry Information

Gene Name	branched chain amino-acid transaminase 1, cytosolic
Protein Entry	BCAT1_HUMAN
UniProt ID	P54687
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P54687-1; Sequence=Displayed; Name=2; IsoId=P54687-2; Sequence=VSP_042651, VSP_042652; Note=No experimental confirmation available.; Name=3; IsoId=P54687-3; Sequence=VSP_042652; Note=No experimental confirmation available.; Name=4; IsoId=P54687-4; Sequence=VSP_043560; Note=No experimental confirmation available.; Name=5; IsoId=P54687-5; Sequence=VSP_046057; Note=No experimental confirmation available.;
Catalytic Activity	L-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate.
Catalytic Activity	L-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate.
Catalytic Activity	L-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate.
Cofactor	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Function	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Similarity	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Homodimer. {ECO:0000250}.
Tissue Specificity	During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.