MitoProteome Database

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MT000073

UniProt Annotations

Entry Information

Gene Name	branched chain amino-acid transaminase 2, mitochondrial
Protein Entry	BCAT2_HUMAN
UniProt ID	O15382
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=O15382-1; Sequence=Displayed; Name=B; IsoId=O15382-2; Sequence=VSP_000236;
Catalytic Activity	L-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate.
Catalytic Activity	L-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate.
Catalytic Activity	L-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate.
Cofactor	Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Function	Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
Sequence Caution	Sequence=AAB53087.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular Location	Isoform A: Mitochondrion.
Subcellular Location	Isoform B: Cytoplasm.
Subunit	Homodimer. {ECO:0000269\|PubMed:11264579}.
Tissue Specificity	Ubiquitous.