MitoProteome Database

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MT000078

Gene Information

Entrez Gene ID598
Gene NameBCL2-like 1
Gene SymbolBCL2L1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097136 IDA:UniProtKBCBcl-2 family protein complex
GO:0030054 IEA:UniProtKB-KWCcell junction
GO:0005813 IDA:UniProtKBCcentrosome
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0031410 IEA:UniProtKB-KWCcytoplasmic vesicle
GO:0005829 IEA:EnsemblCcytosol
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005743 IEA:UniProtKB-KWCmitochondrial inner membrane
GO:0005741 IDA:UniProtKBCmitochondrial outer membrane
GO:0005739 IDA:HGNCCmitochondrion
GO:0005730 IDA:HPACnucleolus
GO:0005634 IDA:HPACnucleus
GO:0045202 IEA:UniProtKB-KWCsynapse
GO:0051434 IPI:UniProtFBH3 domain binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0046982 IBA:RefGenomeFprotein heterodimerization activity
GO:0042803 IBA:RefGenomeFprotein homodimerization activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0008637 TAS:ProtIncPapoptotic mitochondrial changes
GO:0006915 TAS:ReactomePapoptotic process
GO:0071839 IEA:EnsemblPapoptotic process in bone marrow
GO:0008283 IEA:EnsemblPcell proliferation
GO:0060154 IEA:EnsemblPcellular process regulating host cell cycle in response to virus
GO:0071312 IEA:EnsemblPcellular response to alkaloid
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0071480 IEA:EnsemblPcellular response to gamma radiation
GO:0000910 IMP:UniProtKBPcytokinesis
GO:0006897 IEA:UniProtKB-KWPendocytosis
GO:0097192 IBA:RefGenomePextrinsic apoptotic signaling pathway in absence of ligand
GO:0009566 IEA:EnsemblPfertilization
GO:0007281 IEA:EnsemblPgerm cell development
GO:0040007 IEA:EnsemblPgrowth
GO:0097284 IEA:EnsemblPhepatocyte apoptotic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0008584 IEA:EnsemblPmale gonad development
GO:0070584 IEA:EnsemblPmitochondrion morphogenesis
GO:0007093 IMP:UniProtKBPmitotic cell cycle checkpoint
GO:2000811 IMP:UniProtKBPnegative regulation of anoikis
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0010507 TAS:UniProtKBPnegative regulation of autophagy
GO:0090005 IDA:BHF-UCLPnegative regulation of establishment of protein localization to plasma membrane
GO:1900118 IDA:UniProtKBPnegative regulation of execution phase of apoptosis
GO:2001240 TAS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 IDA:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway
GO:1902230 IDA:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0090201 IC:BHF-UCLPnegative regulation of release of cytochrome c from mitochondria
GO:0051402 IEA:EnsemblPneuron apoptotic process
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0001541 IEA:EnsemblPovarian follicle development
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0008284 IEA:EnsemblPpositive regulation of cell proliferation
GO:2001244 TAS:ReactomePpositive regulation of intrinsic apoptotic signaling pathway
GO:0046902 IDA:HGNCPregulation of mitochondrial membrane permeability
GO:0051881 IDA:HGNCPregulation of mitochondrial membrane potential
GO:0001836 IDA:HGNCPrelease of cytochrome c from mitochondria
GO:0046898 IEA:EnsemblPresponse to cycloheximide
GO:0034097 IDA:MGIPresponse to cytokine
GO:0007283 IEA:EnsemblPspermatogenesis
GO:0019050 IDA:MGIPsuppression by virus of host apoptotic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05014Amyotrophic lateral sclerosis (ALS)
ko05014Amyotrophic lateral sclerosis (ALS)
hsa04210Apoptosis
ko04210Apoptosis
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05166HTLV-I infection
ko05166HTLV-I infection
hsa04630Jak-STAT signaling pathway
ko04630Jak-STAT signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa04014Ras signaling pathway
hsa05222Small cell lung cancer
ko05222Small cell lung cancer
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05202Transcriptional misregulation in cancer
ko05202Transcriptional misregulation in cancer
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_578Apoptosis
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75927The NLRP1 inflammasome