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MT000086

UniProt Annotations

Entry Information

Gene Name	BCL2/adenovirus E1B 19kDa interacting protein 1
Protein Entry	SEC20_HUMAN
UniProt ID	Q12981
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=BNIP1, S4; IsoId=Q12981-4; Sequence=Displayed; Name=2; Synonyms=BNIP1-a, S1; IsoId=Q12981-2; Sequence=VSP_004330; Name=3; Synonyms=BNIP1-b, S2; IsoId=Q12981-1; Sequence=VSP_017901; Name=4; Synonyms=BNIP1-c, S3; IsoId=Q12981-3; Sequence=VSP_017901, VSP_004330;
Function	SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. {ECO:0000269\|PubMed:15272311, ECO:0000269\|PubMed:21931693}.
Miscellaneous	Silencing of BNIP1 disrupts ER morphology.
Ptm	'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy. {ECO:0000269\|PubMed:21931693}.
Similarity	Belongs to the SEC20 family. {ECO:0000305}.
Subcellular Location	Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Subunit	Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein. {ECO:0000269\|PubMed:15272311}.
Tissue Specificity	Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine. {ECO:0000269\|PubMed:10217402}.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bnip1/";