MitoProteome Database

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MT000091

Gene Information

Entrez Gene ID673
Gene NameB-Raf proto-oncogene, serine/threonine kinase
Gene SymbolBRAF
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0044297 IEA:EnsemblCcell body
GO:0005829 TAS:ReactomeCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0043005 IEA:EnsemblCneuron projection
GO:0005634 IEA:UniProtKB-KWCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005509 IDA:BHF-UCLFcalcium ion binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004709 IEA:EnsemblFMAP kinase kinase kinase activity
GO:0004672 IDA:BHF-UCLFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0043367 IEA:EnsemblPCD4-positive, alpha-beta T cell differentiation
GO:0071277 IDA:BHF-UCLPcellular response to calcium ion
GO:0035690 IEA:EnsemblPcellular response to drug
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0060291 IEA:EnsemblPlong-term synaptic potentiation
GO:0002318 IEA:EnsemblPmyeloid progenitor cell differentiation
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:2000352 IEA:EnsemblPnegative regulation of endothelial cell apoptotic process
GO:0010764 IEA:EnsemblPnegative regulation of fibroblast migration
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:2000301 IEA:EnsemblPnegative regulation of synaptic vesicle exocytosis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009887 TAS:ProtIncPorgan morphogenesis
GO:0070374 IDA:BHF-UCLPpositive regulation of ERK1 and ERK2 cascade
GO:0010628 IMP:BHF-UCLPpositive regulation of gene expression
GO:0033138 IDA:UniProtKBPpositive regulation of peptidyl-serine phosphorylation
GO:0051496 IEA:EnsemblPpositive regulation of stress fiber assembly
GO:1900026 IEA:EnsemblPpositive regulation of substrate adhesion-dependent cell spreading
GO:0043368 IEA:EnsemblPpositive T cell selection
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0006468 IDA:BHF-UCLPprotein phosphorylation
GO:0042127 IEA:EnsemblPregulation of cell proliferation
GO:0051591 IEA:EnsemblPresponse to cAMP
GO:0070849 IEA:EnsemblPresponse to epidermal growth factor
GO:0043434 IEA:EnsemblPresponse to peptide hormone
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0035019 IEA:EnsemblPsomatic stem cell maintenance
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0008542 IEA:EnsemblPvisual learning
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05221Acute myeloid leukemia
ko05221Acute myeloid leukemia
hsa05034Alcoholism
ko05034Alcoholism
hsa05219Bladder cancer
ko05219Bladder cancer
hsa04024cAMP signaling pathway
ko04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
ko04062Chemokine signaling pathway
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa05213Endometrial cancer
ko05213Endometrial cancer
hsa04012ErbB signaling pathway
ko04012ErbB signaling pathway
hsa04510Focal adhesion
ko04510Focal adhesion
hsa04068FoxO signaling pathway
hsa05214Glioma
ko05214Glioma
hsa05160Hepatitis C
ko05160Hepatitis C
hsa04910Insulin signaling pathway
ko04910Insulin signaling pathway
hsa04730Long-term depression
ko04730Long-term depression
hsa04720Long-term potentiation
ko04720Long-term potentiation
hsa04010MAPK signaling pathway
ko04010MAPK signaling pathway
hsa05218Melanoma
ko05218Melanoma
hsa04150mTOR signaling pathway
ko04150mTOR signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
ko04650Natural killer cell mediated cytotoxicity
hsa04722Neurotrophin signaling pathway
ko04722Neurotrophin signaling pathway
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa04914Progesterone-mediated oocyte maturation
ko04914Progesterone-mediated oocyte maturation
hsa05215Prostate cancer
ko05215Prostate cancer
hsa05205Proteoglycans in cancer
ko05205Proteoglycans in cancer
hsa04015Rap1 signaling pathway
ko04015Rap1 signaling pathway
hsa04810Regulation of actin cytoskeleton
ko04810Regulation of actin cytoskeleton
hsa05211Renal cell carcinoma
ko05211Renal cell carcinoma
hsa04726Serotonergic synapse
hsa05216Thyroid cancer
ko05216Thyroid cancer
hsa04270Vascular smooth muscle contraction
ko04270Vascular smooth muscle contraction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_12002ARMS-mediated activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_116125Disease
REACT_12076Frs2-mediated activation
REACT_111184Negative regulation of FGFR signaling
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_20593Post NMDA receptor activation events
REACT_12005Prolonged ERK activation events
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_111102Signal Transduction
REACT_111080Spry regulation of FGF signaling
REACT_13477Transmission across Chemical Synapses