MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT000092

UniProt Annotations

Entry Information

Gene Name	basigin (Ok blood group)
Protein Entry	BASI_HUMAN
UniProt ID	P35613
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long, Basigin-2; IsoId=P35613-1; Sequence=Displayed; Name=2; Synonyms=Basigin-1; IsoId=P35613-2; Sequence=VSP_011501; Name=3; Synonyms=Basigin-3; IsoId=P35613-3; Sequence=VSP_043225; Note=Produced by alternative promoter usage. N-glycosylated.; Name=4; Synonyms=Basigin-4; IsoId=P35613-4; Sequence=VSP_043226, VSP_043227; Note=Produced by alternative promoter usage. N-glycosylated.;
Function	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269\|PubMed:17127621}.
Induction	Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
Ptm	N-glycosylated. {ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973}.
Similarity	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
Similarity	Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:15946952}; Single-pass type I membrane protein {ECO:0000303\|PubMed:15946952}. Melanosome {ECO:0000269\|PubMed:17081065}. Note=Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250\|UniProtKB:P18572, ECO:0000269\|PubMed:17081065}.
Subunit	Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. {ECO:0000250\|UniProtKB:P18572, ECO:0000250\|UniProtKB:P26453, ECO:0000269\|PubMed:15946952, ECO:0000269\|PubMed:17127621, ECO:0000269\|PubMed:17267690, ECO:0000269\|PubMed:18430721, ECO:0000269\|PubMed:19768682, ECO:0000269\|PubMed:21536654}.
Tissue Specificity	Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Web Resource	Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok";
Web Resource	Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/bsg/";