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MT000097

Record overview

MITO IDMT000097
Gene ID763
SpeciesHomo sapiens (Human)
Gene Namecarbonic anhydrase VA, mitochondrial
Gene SymbolCA5A
SynonymsCA5; CAV; CAVA; CA5AD;
Alternate namescarbonic anhydrase 5A, mitochondrial; CA-VA; carbonic dehydratase; carbonate dehydratase VA; carbonic anhydrase V, mitochondrial;
Chromosome16
Map Location16q24.3
EC Number4.2.1.1
Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CA5A

Proteins

carbonic anhydrase 5A, mitochondrial precursor
Refseq ID:NP_001730
Protein GI:4502521
UniProt ID:P35218
mRNA ID:NM_001739
Length:305
RefSeq Status:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGY
LFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDIL
PEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATN
EGTRS
 
N
transit_peptide: 1..38
note: mitochondrion
calculated_mol_wt: 4576
peptide sequence: 
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRS

mat_peptide: 39..305
product: carbonic anhydrase 5A, mitochondrial
calculated_mol_wt: 30192
peptide sequence: 
CAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNE
GGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPP
LTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS