MitoProteome Database

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MT000104

UniProt Annotations

Entry Information

Gene Name	caspase 4, apoptosis-related cysteine peptidase
Protein Entry	CASP4_HUMAN
UniProt ID	P49662
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49662-1; Sequence=Displayed; Name=2; IsoId=P49662-2; Sequence=VSP_043495;
Catalytic Activity	Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-\|- but also cleaves at Asp-Glu-Val-Asp-\|-. {ECO:0000269\|Ref.14}.
Enzyme Regulation	Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis. {ECO:0000269\|Ref.14}.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1. {ECO:0000269\|PubMed:15123740, ECO:0000269\|Ref.14}.
Ptm	The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
Similarity	Belongs to the peptidase C14A family. {ECO:0000305}.
Similarity	Contains 1 CARD domain. {ECO:0000255\|PROSITE- ProRule:PRU00046}.
Subcellular Location	Endoplasmic reticulum membrane. Mitochondrion.
Subunit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity). Interacts with NleF from pathogenic E.coli. Interacts with TMEM214, the interaction is required for ER membrane localization. {ECO:0000250, ECO:0000269\|PubMed:23661706, ECO:0000269\|Ref.14}.
Tissue Specificity	Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp4/";