MitoProteome Database

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MT000107

Gene Information

Entrez Gene ID842
Gene Namecaspase 9, apoptosis-related cysteine peptidase
Gene SymbolCASP9
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0043293 IDA:UniProtKBCapoptosome
GO:0005829 IDA:UniProtKBCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005634 IEA:EnsemblCnucleus
GO:0004197 IBA:RefGenomeFcysteine-type endopeptidase activity
GO:0008047 TAS:ProtIncFenzyme activator activity
GO:0008233 IDA:MGIFpeptidase activity
GO:0019901 IDA:UniProtKBFprotein kinase binding
GO:0017124 IDA:UniProtKBFSH3 domain binding
GO:0008635 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568 IEA:EnsemblPaging
GO:0006915 TAS:UniProtKBPapoptotic process
GO:0071549 IEA:EnsemblPcellular response to dexamethasone stimulus
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0034644 IDA:UniProtKBPcellular response to UV
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0034349 IEA:EnsemblPglial cell apoptotic process
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0008630 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030220 TAS:UniProtKBPplatelet formation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0042981 TAS:ReactomePregulation of apoptotic process
GO:2001020 IMP:UniProtKBPregulation of response to DNA damage stimulus
GO:0046677 IEA:EnsemblPresponse to antibiotic
GO:0032025 IEA:EnsemblPresponse to cobalt ion
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0042770 IDA:UniProtKBPsignal transduction in response to DNA damage
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05010Alzheimer's disease
ko05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
ko05014Amyotrophic lateral sclerosis (ALS)
hsa04210Apoptosis
ko04210Apoptosis
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa05213Endometrial cancer
ko05213Endometrial cancer
hsa05161Hepatitis B
hsa05016Huntington's disease
ko05016Huntington's disease
hsa05164Influenza A
ko05164Influenza A
hsa05134Legionellosis
ko05134Legionellosis
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa04115p53 signaling pathway
ko04115p53 signaling pathway
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05012Parkinson's disease
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa05215Prostate cancer
ko05215Prostate cancer
hsa05222Small cell lung cancer
ko05222Small cell lung cancer
hsa04919Thyroid hormone signaling pathway
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
hsa04370VEGF signaling pathway
ko04370VEGF signaling pathway
hsa05416Viral myocarditis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_607Activation of caspases through apoptosome-mediated cleavage
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_578Apoptosis
REACT_963Apoptotic factor-mediated response
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_831Cytochrome c-mediated apoptotic response
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_89Formation of apoptosome
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_13648Regulation of Apoptosis
REACT_22128Role of DCC in regulating apoptosis
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_2190SMAC binds to IAPs
REACT_666SMAC-mediated apoptotic response
REACT_1767SMAC-mediated dissociation of IAP:caspase complexes