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MT000108

UniProt Annotations

Entry Information

Gene Name	calsequestrin 1 (fast-twitch, skeletal muscle)
Protein Entry	CASQ1_HUMAN
UniProt ID	P31415
Species	Human

Comments

Comment type	Description
Function	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. {ECO:0000269\|PubMed:22337878, ECO:0000303\|PubMed:22337878}.
Ptm	N-glycosylated. {ECO:0000250\|UniProtKB:P07221}.
Sequence Caution	Sequence=AAB32063.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH22289.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36060.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the calsequestrin family. {ECO:0000305}.
Subcellular Location	Sarcoplasmic reticulum lumen {ECO:0000250\|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250\|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250\|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. {ECO:0000250\|UniProtKB:P07221}.
Subunit	Interacts with ASPH and TRDN (By similarity). Monomer, homodimer, homotetramer and homopolymer. Can form linear homooligomers. Ca(2+) ions promote oligomerization. {ECO:0000250\|UniProtKB:P07221, ECO:0000269\|PubMed:22337878}.
Web Resource	Name=Wikipedia; Note=Calsequestrin entry; URL="http://en.wikipedia.org/wiki/Calsequestrin";