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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000113
Gene Information
Entrez Gene ID
983
Gene Name
cyclin-dependent kinase 1
Gene Symbol
CDK1
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID
Source
Type
Description
GO:0005813
IDA:UniProtKB
C
centrosome
GO:0005737
IDA:HPA
C
cytoplasm
GO:0005829
TAS:Reactome
C
cytosol
GO:0070062
IDA:UniProt
C
extracellular vesicular exosome
GO:0016020
IDA:UniProtKB
C
membrane
GO:0030496
IDA:UniProtKB
C
midbody
GO:0005739
TAS:UniProtKB
C
mitochondrion
GO:0072686
IDA:UniProtKB
C
mitotic spindle
GO:0005654
TAS:Reactome
C
nucleoplasm
GO:0005634
IDA:HPA
C
nucleus
GO:0005876
IDA:UniProtKB
C
spindle microtubule
GO:0005524
IEA:UniProtKB-KW
F
ATP binding
GO:0004693
IDA:UniProtKB
F
cyclin-dependent protein serine/threonine kinase activity
GO:0035173
IEA:Ensembl
F
histone kinase activity
GO:0004672
NAS:ProtInc
F
protein kinase activity
GO:0004674
IDA:ParkinsonsUK-UCL
F
protein serine/threonine kinase activity
GO:0008353
IDA:UniProtKB
F
RNA polymerase II carboxy-terminal domain kinase activity
GO:0000187
TAS:Reactome
P
activation of MAPK activity
GO:0000186
TAS:Reactome
P
activation of MAPKK activity
GO:0031145
TAS:Reactome
P
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0006915
IEA:UniProtKB-KW
P
apoptotic process
GO:0007411
TAS:Reactome
P
axon guidance
GO:0007569
IEA:Ensembl
P
cell aging
GO:0016477
TAS:UniProtKB
P
cell migration
GO:0070301
IEA:Ensembl
P
cellular response to hydrogen peroxide
GO:0007098
TAS:UniProtKB
P
centrosome cycle
GO:0030261
IEA:Ensembl
P
chromosome condensation
GO:0006281
TAS:UniProtKB
P
DNA repair
GO:0006260
TAS:UniProtKB
P
DNA replication
GO:0007173
TAS:Reactome
P
epidermal growth factor receptor signaling pathway
GO:0030855
IEP:UniProt
P
epithelial cell differentiation
GO:0038095
TAS:Reactome
P
Fc-epsilon receptor signaling pathway
GO:0008543
TAS:Reactome
P
fibroblast growth factor receptor signaling pathway
GO:0000082
TAS:Reactome
P
G1/S transition of mitotic cell cycle
GO:0000086
TAS:Reactome
P
G2/M transition of mitotic cell cycle
GO:0045087
TAS:Reactome
P
innate immune response
GO:0008286
TAS:Reactome
P
insulin receptor signaling pathway
GO:0000165
TAS:Reactome
P
MAPK cascade
GO:0000226
TAS:UniProtKB
P
microtubule cytoskeleton organization
GO:0000278
TAS:Reactome
P
mitotic cell cycle
GO:0007095
IEA:Ensembl
P
mitotic G2 DNA damage checkpoint
GO:0007067
IEA:UniProtKB-KW
P
mitotic nuclear division
GO:0007077
TAS:Reactome
P
mitotic nuclear envelope disassembly
GO:0002755
TAS:Reactome
P
MyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS:Reactome
P
MyD88-independent toll-like receptor signaling pathway
GO:0043066
IDA:UniProtKB
P
negative regulation of apoptotic process
GO:0048011
TAS:Reactome
P
neurotrophin TRK receptor signaling pathway
GO:0031100
IEA:Ensembl
P
organ regeneration
GO:0018105
IDA:ParkinsonsUK-UCL
P
peptidyl-serine phosphorylation
GO:0018107
IDA:ParkinsonsUK-UCL
P
peptidyl-threonine phosphorylation
GO:0060045
IEA:Ensembl
P
positive regulation of cardiac muscle cell proliferation
GO:0045740
IEA:Ensembl
P
positive regulation of DNA replication
GO:0010628
IEA:Ensembl
P
positive regulation of gene expression
GO:0045931
IEA:Ensembl
P
positive regulation of mitotic cell cycle
GO:0033160
IEA:Ensembl
P
positive regulation of protein import into nucleus, translocation
GO:0051437
TAS:Reactome
P
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007344
TAS:UniProtKB
P
pronuclear fusion
GO:0006461
IEA:Ensembl
P
protein complex assembly
GO:0034501
IDA:BHF-UCL
P
protein localization to kinetochore
GO:0007265
TAS:Reactome
P
Ras protein signal transduction
GO:0045995
TAS:UniProtKB
P
regulation of embryonic development
GO:0014038
TAS:UniProtKB
P
regulation of Schwann cell differentiation
GO:0000083
TAS:Reactome
P
regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0051439
TAS:Reactome
P
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0014823
IEA:Ensembl
P
response to activity
GO:0014075
IEA:Ensembl
P
response to amine
GO:0048678
IEA:Ensembl
P
response to axon injury
GO:0046686
IEA:Ensembl
P
response to cadmium ion
GO:0046688
IEA:Ensembl
P
response to copper ion
GO:0042493
IEA:Ensembl
P
response to drug
GO:0045471
IEA:Ensembl
P
response to ethanol
GO:0014070
IEA:Ensembl
P
response to organic cyclic compound
GO:0009636
IEA:Ensembl
P
response to toxic substance
GO:0007264
TAS:Reactome
P
small GTPase mediated signal transduction
GO:0051403
TAS:Reactome
P
stress-activated MAPK cascade
GO:0034166
TAS:Reactome
P
toll-like receptor 10 signaling pathway
GO:0034134
TAS:Reactome
P
toll-like receptor 2 signaling pathway
GO:0034138
TAS:Reactome
P
toll-like receptor 3 signaling pathway
GO:0034142
TAS:Reactome
P
toll-like receptor 4 signaling pathway
GO:0034146
TAS:Reactome
P
toll-like receptor 5 signaling pathway
GO:0034162
TAS:Reactome
P
toll-like receptor 9 signaling pathway
GO:0002224
TAS:Reactome
P
toll-like receptor signaling pathway
GO:0038123
TAS:Reactome
P
toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS:Reactome
P
toll-like receptor TLR6:TLR2 signaling pathway
GO:0035666
TAS:Reactome
P
TRIF-dependent toll-like receptor signaling pathway
GO:0055015
IEA:Ensembl
P
ventricular cardiac muscle cell development
KEGG Pathway Links
KEGG Pathway ID
Description
hsa04110
Cell cycle
ko04110
Cell cycle
hsa05169
Epstein-Barr virus infection
ko05169
Epstein-Barr virus infection
hsa04540
Gap junction
ko04540
Gap junction
hsa05168
Herpes simplex infection
ko05168
Herpes simplex infection
hsa04114
Oocyte meiosis
ko04114
Oocyte meiosis
hsa04115
p53 signaling pathway
ko04115
p53 signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
ko04914
Progesterone-mediated oocyte maturation
hsa05203
Viral carcinogenesis
ko05203
Viral carcinogenesis
REACTOME Pathway Links
REACTOME Pathway ID
Description
REACT_6890
Activated TLR4 signalling
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_160122
Activation of NIMA Kinases NEK9, NEK6, NEK7
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_6828
APC/C-mediated degradation of cell cycle proteins
REACT_12002
ARMS-mediated activation
REACT_18266
Axon guidance
REACT_115566
Cell Cycle
REACT_1538
Cell Cycle Checkpoints
REACT_152
Cell Cycle, Mitotic
REACT_15479
Centrosome maturation
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REACT_150260
Condensation of Prometaphase Chromosomes
REACT_172744
Condensation of Prophase Chromosomes
REACT_1857
Cyclin A/B1 associated events during G2/M transition
REACT_2101
Cyclin B2 mediated events
REACT_75790
Cytokine Signaling in Immune system
REACT_147694
DAP12 interactions
REACT_147814
DAP12 signaling
REACT_200828
Depolymerisation of the Nuclear Lamina
REACT_111045
Developmental Biology
REACT_116125
Disease
REACT_21272
Downstream signaling of activated FGFR
REACT_17025
Downstream signal transduction
REACT_1321
E2F-enabled inhibition of pre-replication complex formation
REACT_471
E2F mediated regulation of DNA replication
REACT_1391
ERK1 activation
REACT_1482
ERK activation
REACT_163936
Fc epsilon receptor (FCERI) signaling
REACT_163701
FCERI mediated MAPK activation
REACT_12076
Frs2-mediated activation
REACT_21247
FRS2-mediated cascade
REACT_111214
G0 and Early G1
REACT_683
G1/S-Specific Transcription
REACT_1783
G1/S Transition
REACT_828
G2/M Checkpoints
REACT_897
G2/M DNA damage checkpoint
REACT_1846
G2/M DNA replication checkpoint
REACT_2203
G2/M Transition
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK
REACT_1100
Golgi Cisternae Pericentriolar Stack Reorganization
REACT_12606
GRB2 events in EGFR signaling
REACT_115854
GRB2 events in ERBB2 signaling
REACT_150210
IGF1R signaling cascade
REACT_6900
Immune System
REACT_6802
Innate Immune System
REACT_1195
Insulin receptor signalling cascade
REACT_27283
Interleukin-2 signaling
REACT_332
IRS-mediated signalling
REACT_762
IRS-related events
REACT_150203
IRS-related events triggered by IGF1R
REACT_15364
Loss of Nlp from mitotic centrosomes
REACT_15451
Loss of proteins required for interphase microtubule organization from the centrosome
REACT_21308
MAP kinase activation in TLR cascade
REACT_150182
MASTL Facilitates Mitotic Progression
REACT_21267
Mitotic G1-G1/S phases
REACT_21391
Mitotic G2-G2/M phases
REACT_682
Mitotic Prometaphase
REACT_765
Mitotic Prophase
REACT_910
M Phase
REACT_27215
MyD88 cascade initiated on plasma membrane
REACT_25222
MyD88 dependent cascade initiated on endosome
REACT_6809
MyD88-independent cascade
REACT_6788
MyD88:Mal cascade initiated on plasma membrane
REACT_18334
NCAM signaling for neurite out-growth
REACT_12056
NGF signalling via TRKA from the plasma membrane
REACT_160255
Nuclear Envelope Breakdown
REACT_163931
Nuclear Pore Complex (NPC) Disassembly
REACT_6875
Phosphorylation of Emi1
REACT_6362
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
REACT_6904
Phosphorylation of the APC/C
REACT_12005
Prolonged ERK activation events
REACT_634
RAF/MAP kinase cascade
REACT_15296
Recruitment of mitotic centrosome proteins and complexes
REACT_15510
Recruitment of NuMA to mitotic centrosomes
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase
REACT_21279
Regulation of mitotic cell cycle
REACT_160315
Regulation of PLK1 Activity at G2/M Transition
REACT_150425
Resolution of Sister Chromatid Cohesion
REACT_12579
SHC1 events in EGFR signaling
REACT_115993
SHC1 events in ERBB2 signaling
REACT_116005
SHC1 events in ERBB4 signaling
REACT_661
SHC-mediated signalling
REACT_999
SHC-related events
REACT_150139
SHC-related events triggered by IGF1R
REACT_9417
Signaling by EGFR
REACT_115871
Signaling by EGFR in Cancer
REACT_115755
Signaling by ERBB2
REACT_115596
Signaling by ERBB4
REACT_9470
Signaling by FGFR
REACT_120736
Signaling by FGFR in disease
REACT_14797
Signaling by GPCR
REACT_498
Signaling by Insulin receptor
REACT_22232
Signaling by Interleukins
REACT_169118
Signaling by Leptin
REACT_16888
Signaling by PDGF
REACT_111040
Signaling by SCF-KIT
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529
Signaling by VEGF
REACT_11061
Signalling by NGF
REACT_12058
Signalling to ERKs
REACT_12077
Signalling to p38 via RIT and RIN
REACT_12033
Signalling to RAS
REACT_111102
Signal Transduction
REACT_524
SOS-mediated signalling
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade
REACT_6966
Toll-Like Receptors Cascades
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281
TRIF-mediated TLR3/TLR4 signaling
REACT_228166
VEGFA-VEGFR2 Pathway
REACT_228024
VEGFR2 mediated cell proliferation
MitoProteome Human Mitochondrial Protein Database
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