MitoProteome Database

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MT000115

Gene Information

Entrez Gene ID1029
Gene Namecyclin-dependent kinase inhibitor 2A
Gene SymbolCDKN2A
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005739 IEA:UniProtKB-KWCmitochondrion
GO:0005730 IDA:BHF-UCLCnucleolus
GO:0005654 IDA:BHF-UCLCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0043234 IDA:BHF-UCLCprotein complex
GO:0003677 IEA:UniProtKB-KWFDNA binding
GO:0097371 IPI:BHF-UCLFMDM2/MDM4 family protein binding
GO:0002039 IPI:BHF-UCLFp53 binding
GO:0008134 IPI:BHF-UCLFtranscription factor binding
GO:0055105 ISS:BHF-UCLFubiquitin-protein transferase inhibitor activity
GO:0006919 IMP:BHF-UCLPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008637 IMP:BHF-UCLPapoptotic mitochondrial changes
GO:0007050 IMP:BHF-UCLPcell cycle arrest
GO:0090398 IMP:BHF-UCLPcellular senescence
GO:0030889 ISS:BHF-UCLPnegative regulation of B cell proliferation
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0033088 ISS:BHF-UCLPnegative regulation of immature T cell proliferation in thymus
GO:0006469 IMP:BHF-UCLPnegative regulation of protein kinase activity
GO:0051444 ISS:BHF-UCLPnegative regulation of ubiquitin-protein transferase activity
GO:0071158 IDA:BHF-UCLPpositive regulation of cell cycle arrest
GO:0043517 IDA:BHF-UCLPpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0033235 IMP:BHF-UCLPpositive regulation of protein sumoylation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0031648 IDA:BHF-UCLPprotein destabilization
GO:0070534 IDA:UniProtKBPprotein K63-linked ubiquitination
GO:0000209 IDA:UniProtKBPprotein polyubiquitination
GO:0050821 IDA:BHF-UCLPprotein stabilization
GO:1902510 IMP:BHF-UCLPregulation of apoptotic DNA fragmentation
GO:0010389 IMP:BHF-UCLPregulation of G2/M transition of mitotic cell cycle
GO:0046825 IMP:BHF-UCLPregulation of protein export from nucleus
GO:0031647 ISS:BHF-UCLPregulation of protein stability
GO:0006364 IEA:UniProtKB-KWPrRNA processing
GO:0048103 ISS:BHF-UCLPsomatic stem cell division
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05219Bladder cancer
ko05219Bladder cancer
hsa04110Cell cycle
ko04110Cell cycle
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05214Glioma
ko05214Glioma
hsa05166HTLV-I infection
ko05166HTLV-I infection
hsa05218Melanoma
ko05218Melanoma
hsa05206MicroRNAs in cancer
ko05206MicroRNAs in cancer
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa04115p53 signaling pathway
ko04115p53 signaling pathway
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa05203Viral carcinogenesis
ko05203Viral carcinogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_821Cyclin D associated events in G1
REACT_1590G1 Phase
REACT_21267Mitotic G1-G1/S phases
REACT_169325Oncogene Induced Senescence
REACT_169436Oxidative Stress Induced Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)