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MT000116

UniProt Annotations

Entry Information

Gene Name	CCAAT/enhancer binding protein (C/EBP), alpha
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Function	C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.
Interaction	P47902:CDX1; NbExp=3; IntAct=EBI-1172054, EBI-8514176; P03122:E2 (xeno); NbExp=2; IntAct=EBI-1172054, EBI-7028618; P06422:E2 (xeno); NbExp=4; IntAct=EBI-1172054, EBI-7136851; P09874:PARP1; NbExp=2; IntAct=EBI-1172054, EBI-355676;
Similarity	Belongs to the bZIP family. C/EBP subfamily. {ECO:0000305}.
Similarity	Contains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255\|PROSITE-ProRule:PRU00978}.
Subcellular Location	Nucleus.
Subunit	Interacts with PRDM16 (By similarity). Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X. Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). {ECO:0000250}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CEBPAID40050ch19q13.html";
Web Resource	Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cebpa/";