MitoProteome Database

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MT000120

UniProt Annotations

Entry Information

Gene Name	creatine kinase, mitochondrial 2 (sarcomeric)
Protein Entry	KCRS_HUMAN
UniProt ID	P17540
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + creatine = ADP + phosphocreatine. {ECO:0000255\|PROSITE-ProRule:PRU10029}.
Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Miscellaneous	Mitochondrial creatine kinase binds cardiolipin.
Similarity	Belongs to the ATP:guanido phosphotransferase family. {ECO:0000255\|PROSITE-ProRule:PRU00842, ECO:0000255\|PROSITE- ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase N-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00842}.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Subunit	Exists as an octamer composed of four CKMT2 homodimers. {ECO:0000269\|Ref.5}.
Tissue Specificity	Sarcomere-specific. Found only in heart and skeletal muscles.