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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000122
Gene Information
Entrez Gene ID
1191
Gene Name
clusterin
Gene Symbol
CLU
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID
Source
Type
Description
GO:0097440
IDA:Alzheimers_University_of_Toronto
C
apical dendrite
GO:0072562
IDA:UniProt
C
blood microparticle
GO:0005737
IDA:Alzheimers_University_of_Toronto
C
cytoplasm
GO:0005783
IEA:UniProtKB-KW
C
endoplasmic reticulum
GO:0031012
IDA:UniProtKB
C
extracellular matrix
GO:0005576
TAS:Reactome
C
extracellular region
GO:0005615
IDA:UniProtKB
C
extracellular space
GO:0070062
IDA:UniProtKB
C
extracellular vesicular exosome
GO:0016020
IEA:UniProtKB-KW
C
membrane
GO:0005739
IDA:BHF-UCL
C
mitochondrion
GO:0097418
IDA:Alzheimers_University_of_Toronto
C
neurofibrillary tangle
GO:0005634
IEA:UniProtKB-KW
C
nucleus
GO:0048471
IDA:UniProtKB
C
perinuclear region of cytoplasm
GO:0031093
TAS:Reactome
C
platelet alpha granule lumen
GO:0034366
IDA:BHF-UCL
C
spherical high-density lipoprotein particle
GO:0051787
IDA:UniProtKB
F
misfolded protein binding
GO:0031625
IDA:UniProtKB
F
ubiquitin protein ligase binding
GO:0007596
TAS:Reactome
P
blood coagulation
GO:0000902
IDA:Alzheimers_University_of_Toronto
P
cell morphogenesis
GO:0032286
IMP:Alzheimers_University_of_Toronto
P
central nervous system myelin maintenance
GO:0051131
IDA:Alzheimers_University_of_Toronto
P
chaperone-mediated protein complex assembly
GO:0061077
IDA:UniProtKB
P
chaperone-mediated protein folding
GO:0006956
TAS:ProtInc
P
complement activation
GO:0006958
IEA:UniProtKB-KW
P
complement activation, classical pathway
GO:0045087
IEA:UniProtKB-KW
P
innate immune response
GO:0097193
IDA:UniProtKB
P
intrinsic apoptotic signaling pathway
GO:0006629
NAS:ProtInc
P
lipid metabolic process
GO:0001774
IDA:Alzheimers_University_of_Toronto
P
microglial cell activation
GO:0061518
IDA:Alzheimers_University_of_Toronto
P
microglial cell proliferation
GO:1902430
IDA:Alzheimers_University_of_Toronto
P
negative regulation of beta-amyloid formation
GO:1902230
IMP:BHF-UCL
P
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032463
IMP:BHF-UCL
P
negative regulation of protein homooligomerization
GO:0030168
TAS:Reactome
P
platelet activation
GO:0002576
TAS:Reactome
P
platelet degranulation
GO:0043065
IMP:UniProtKB
P
positive regulation of apoptotic process
GO:1902004
ISS:Alzheimers_University_of_Toronto
P
positive regulation of beta-amyloid formation
GO:2001244
IMP:UniProtKB
P
positive regulation of intrinsic apoptotic signaling pathway
GO:1902998
IMP:Alzheimers_University_of_Toronto
P
positive regulation of neurofibrillary tangle assembly
GO:1901216
IDA:Alzheimers_University_of_Toronto
P
positive regulation of neuron death
GO:0051092
IMP:UniProtKB
P
positive regulation of NF-kappaB transcription factor activity
GO:0045429
IDA:Alzheimers_University_of_Toronto
P
positive regulation of nitric oxide biosynthetic process
GO:0032436
IMP:UniProtKB
P
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:2000060
IMP:UniProtKB
P
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1902949
IMP:Alzheimers_University_of_Toronto
P
positive regulation of tau-protein kinase activity
GO:0032760
IDA:Alzheimers_University_of_Toronto
P
positive regulation of tumor necrosis factor production
GO:0017038
IDA:Alzheimers_University_of_Toronto
P
protein import
GO:0050821
IDA:UniProtKB
P
protein stabilization
GO:1900221
IDA:Alzheimers_University_of_Toronto
P
regulation of beta-amyloid clearance
GO:1902847
IMP:Alzheimers_University_of_Toronto
P
regulation of neuronal signal transduction
GO:1901214
IDA:Alzheimers_University_of_Toronto
P
regulation of neuron death
GO:0001836
IC:BHF-UCL
P
release of cytochrome c from mitochondria
GO:0051788
IDA:BHF-UCL
P
response to misfolded protein
GO:0009615
IEP:UniProtKB
P
response to virus
GO:0043691
TAS:BHF-UCL
P
reverse cholesterol transport
REACTOME Pathway Links
REACTOME Pathway ID
Description
REACT_604
Hemostasis
REACT_798
Platelet activation, signaling and aggregation
REACT_318
Platelet degranulation
REACT_1280
Response to elevated platelet cytosolic Ca2+
MitoProteome Human Mitochondrial Protein Database
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