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MT000149

UniProt Annotations

Entry Information

Gene Name	carnitine O-acetyltransferase
Protein Entry	CACP_HUMAN
UniProt ID	P43155
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=SM-1400; IsoId=P43155-1; Sequence=Displayed; Name=2; Synonyms=SM-1200; IsoId=P43155-2; Sequence=VSP_000792; Note=No experimental confirmation available.; Name=3; IsoId=P43155-3; Sequence=VSP_012798;
Catalytic Activity	Acetyl-CoA + carnitine = CoA + O- acetylcarnitine.
Function	Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
Similarity	Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subcellular Location	Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Subcellular Location	Isoform 1: Mitochondrion {ECO:0000305}.
Subcellular Location	Isoform 2: Peroxisome {ECO:0000305}.
Subunit	Monomer. {ECO:0000269\|PubMed:12562770, ECO:0000269\|PubMed:15099582}.
Tissue Specificity	Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.