MitoProteome Database

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MT000150

Gene Information

Entrez Gene ID1386
Gene Nameactivating transcription factor 2
Gene SymbolATF2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005741 IDA:UniProtKBCmitochondrial outer membrane
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0035861 IDA:UniProtKBCsite of double-strand break
GO:0035497 IDA:BHF-UCLFcAMP response element binding
GO:0008140 IDA:BHF-UCLFcAMP response element binding protein binding
GO:0003682 IEA:EnsemblFchromatin binding
GO:0004402 IDA:UniProtKBFhistone acetyltransferase activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0001102 IPI:BHF-UCLFRNA polymerase II activating transcription factor binding
GO:0001077 IEA:EnsemblFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000980 IDA:BHF-UCLFRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003705 IC:BHF-UCLFRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0000977 IMP:NTNU_SBFRNA polymerase II regulatory region sequence-specific DNA binding
GO:0001076 IC:BHF-UCLFRNA polymerase II transcription factor binding transcription factor activity
GO:0001228 IC:NTNU_SBFRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 IDA:MGIFsequence-specific DNA binding transcription factor activity
GO:0003713 TAS:ProtIncFtranscription coactivator activity
GO:0060612 IEA:EnsemblPadipose tissue development
GO:0006974 IDA:UniProtKBPcellular response to DNA damage stimulus
GO:0006325 TAS:ReactomePchromatin organization
GO:0045444 IEA:EnsemblPfat cell differentiation
GO:0016573 IDA:GOCPhistone acetylation
GO:0045087 TAS:ReactomePinnate immune response
GO:0031573 IMP:UniProtKBPintra-S DNA damage checkpoint
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0003151 IEA:EnsemblPoutflow tract morphogenesis
GO:1902110 IMP:UniProtKBPpositive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0051091 IMP:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944 IDA:NTNU_SBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032915 IEA:EnsemblPpositive regulation of transforming growth factor beta2 production
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0006355 IMP:UniProtKBPregulation of transcription, DNA-templated
GO:0006357 IC:BHF-UCLPregulation of transcription from RNA polymerase II promoter
GO:0006970 IDA:UniProtKBPresponse to osmotic stress
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006366 IC:GOCPtranscription from RNA polymerase II promoter
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04261Adrenergic signaling in cardiomyocytes
ko04261Adrenergic signaling in cardiomyocytes
hsa05034Alcoholism
ko05034Alcoholism
hsa05031Amphetamine addiction
ko05031Amphetamine addiction
hsa04022cGMP-PKG signaling pathway
ko04022cGMP-PKG signaling pathway
hsa05030Cocaine addiction
ko05030Cocaine addiction
hsa04728Dopaminergic synapse
ko04728Dopaminergic synapse
hsa05169Epstein-Barr virus infection
ko05169Epstein-Barr virus infection
hsa04915Estrogen signaling pathway
ko04915Estrogen signaling pathway
hsa05161Hepatitis B
hsa05166HTLV-I infection
ko05166HTLV-I infection
hsa05164Influenza A
ko05164Influenza A
hsa04911Insulin secretion
hsa04010MAPK signaling pathway
ko04010MAPK signaling pathway
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa04918Thyroid hormone synthesis
ko04918Thyroid hormone synthesis
hsa04668TNF signaling pathway
ko04668TNF signaling pathway
hsa05203Viral carcinogenesis
ko05203Viral carcinogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_21326Activation of the AP-1 family of transcription factors
REACT_172633Chromatin modifying enzymes
REACT_172623Chromatin organization
REACT_24941Circadian Clock
REACT_172610HATs acetylate histones
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_200788Mitochondrial biogenesis
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_200751Organelle biogenesis and maintenance
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_200608Transcriptional activation of mitochondrial biogenesis
REACT_25281TRIF-mediated TLR3/TLR4 signaling