MitoProteome Database

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MT000153

UniProt Annotations

Entry Information

Gene Name	crystallin, mu
Protein Entry	CRYM_HUMAN
UniProt ID	Q14894
Species	Human

Comments

Comment type	Description
Biophysicochemical Properties	Kinetic parameters: KM=47 uM for 3,4-dehydro-thiomorpholine-3-carboxylate (at pH 5.0 and 37 degrees Celsius) {ECO:0000269\|PubMed:21332720}; KM=3.6 uM for NADH (at pH 5.0 and 37 degrees Celsius) {ECO:0000269\|PubMed:21332720}; Vmax=9.6 umol/min/mg enzyme with 3,4-dehydro-thiomorpholine-3- carboxylate as substrate (at pH 5.0 and 37 degrees Celsius) {ECO:0000269\|PubMed:21332720}; pH dependence: Optimum pH is 4.5. {ECO:0000269\|PubMed:21332720};
Catalytic Activity	Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H. {ECO:0000269\|PubMed:21332720}.
Cofactor	Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000269\|PubMed:17242435, ECO:0000269\|PubMed:21332720}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000269\|PubMed:17242435, ECO:0000269\|PubMed:21332720};
Function	Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269\|PubMed:21332720}.
Similarity	Belongs to the ornithine cyclodeaminase family. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Homodimer. {ECO:0000269\|PubMed:17242435}.
Tissue Specificity	Expressed in neural tissue, muscle and kidney.