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MitoProteome Human Mitochondrial Protein Database
MitoProteome Database
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Related Proteins
MT000170
Gene Information
Entrez Gene ID
1586
Gene Name
cytochrome P450, family 17, subfamily A, polypeptide 1
Gene Symbol
CYP17A1
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID
Source
Type
Description
GO:0030424
IEA:Ensembl
C
axon
GO:0005783
NAS:ProtInc
C
endoplasmic reticulum
GO:0005789
TAS:Reactome
C
endoplasmic reticulum membrane
GO:0005739
IEA:Ensembl
C
mitochondrion
GO:0043025
IEA:Ensembl
C
neuronal cell body
GO:0047442
IEA:UniProtKB-EC
F
17-alpha-hydroxyprogesterone aldolase activity
GO:0020037
IDA:UniProtKB
F
heme binding
GO:0005506
IEA:InterPro
F
iron ion binding
GO:0019825
TAS:ProtInc
F
oxygen binding
GO:0004508
IDA:UniProtKB
F
steroid 17-alpha-monooxygenase activity
GO:0030325
IEA:Ensembl
P
adrenal gland development
GO:0006702
TAS:Reactome
P
androgen biosynthetic process
GO:0018879
IEA:Ensembl
P
biphenyl metabolic process
GO:0071236
IEA:Ensembl
P
cellular response to antibiotic
GO:0071371
IEA:Ensembl
P
cellular response to gonadotropin stimulus
GO:0071222
IEA:Ensembl
P
cellular response to lipopolysaccharide
GO:0018894
IEA:Ensembl
P
dibenzo-p-dioxin metabolic process
GO:0006704
TAS:Reactome
P
glucocorticoid biosynthetic process
GO:0021766
IEA:Ensembl
P
hippocampus development
GO:0042446
IDA:UniProtKB
P
hormone biosynthetic process
GO:0033327
IEA:Ensembl
P
Leydig cell differentiation
GO:0030728
IEA:Ensembl
P
ovulation
GO:0018958
IEA:Ensembl
P
phenol-containing compound metabolic process
GO:0018963
IEA:Ensembl
P
phthalate metabolic process
GO:0090031
IEA:Ensembl
P
positive regulation of steroid hormone biosynthetic process
GO:0042448
IDA:UniProtKB
P
progesterone metabolic process
GO:0010034
IEA:Ensembl
P
response to acetate
GO:0051591
IEA:Ensembl
P
response to cAMP
GO:0034097
IEA:Ensembl
P
response to cytokine
GO:0042493
IEA:Ensembl
P
response to drug
GO:0060992
IEA:Ensembl
P
response to fungicide
GO:0009635
IEA:Ensembl
P
response to herbicide
GO:0017085
IEA:Ensembl
P
response to insecticide
GO:0010212
IEA:Ensembl
P
response to ionizing radiation
GO:0051597
IEA:Ensembl
P
response to methylmercury
GO:0031667
IEA:Ensembl
P
response to nutrient levels
GO:0032526
IEA:Ensembl
P
response to retinoic acid
GO:0048545
IEA:Ensembl
P
response to steroid hormone
GO:0007548
TAS:ProtInc
P
sex differentiation
GO:0044281
TAS:Reactome
P
small molecule metabolic process
GO:0006694
TAS:ProtInc
P
steroid biosynthetic process
GO:0008202
IDA:UniProtKB
P
steroid metabolic process
GO:0016125
TAS:Reactome
P
sterol metabolic process
GO:0006805
TAS:Reactome
P
xenobiotic metabolic process
KEGG Pathway Links
KEGG Pathway ID
Description
hsa_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
hsa_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
hsa01100
Metabolic pathways
hsa04913
Ovarian steroidogenesis
ko04913
Ovarian steroidogenesis
hsa04917
Prolactin signaling pathway
ko04917
Prolactin signaling pathway
hsa00140
Steroid hormone biosynthesis
ko00140
Steroid hormone biosynthesis
BIOCYC Pathway Links
BIOCYC Pathway ID
Description
PWY66-378
androgen biosynthesis
PWY66-378
androgen biosynthesis
PWY66-381
glucocorticoid biosynthesis
PWY66-381
glucocorticoid biosynthesis
PWY-7305
superpathway of steroid hormone biosynthesis
REACTOME Pathway Links
REACTOME Pathway ID
Description
REACT_11059
Androgen biosynthesis
REACT_13433
Biological oxidations
REACT_13567
Cytochrome P450 - arranged by substrate type
REACT_13812
Endogenous sterols
REACT_11036
Glucocorticoid biosynthesis
REACT_111217
Metabolism
REACT_22258
Metabolism of lipids and lipoproteins
REACT_11057
Metabolism of steroid hormones and vitamin D
REACT_13705
Phase 1 - Functionalization of compounds
MitoProteome Human Mitochondrial Protein Database
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