MitoProteome Database

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MT000172

Gene Information

Entrez Gene ID1593
Gene Namecytochrome P450, family 27, subfamily A, polypeptide 1
Gene SymbolCYP27A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005743 IEA:EnsemblCmitochondrial inner membrane
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0047749 IEA:UniProtKB-ECFcholestanetriol 26-monooxygenase activity
GO:0031073 IEA:EnsemblFcholesterol 26-hydroxylase activity
GO:0020037 IEA:InterProFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0008395 TAS:ProtIncFsteroid hydroxylase activity
GO:0030343 IEA:EnsemblFvitamin D3 25-hydroxylase activity
GO:0006699 TAS:ReactomePbile acid biosynthetic process
GO:0008206 TAS:ReactomePbile acid metabolic process
GO:0008203 IEA:EnsemblPcholesterol metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
hsa_M00104Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00104Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
ko03320PPAR signaling pathway
hsa00120Primary bile acid biosynthesis
ko00120Primary bile acid biosynthesis
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-6061bile acid biosynthesis, neutral pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11040Bile acid and bile salt metabolism
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13812Endogenous sterols
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_13705Phase 1 - Functionalization of compounds
REACT_11054Synthesis of bile acids and bile salts
REACT_11053Synthesis of bile acids and bile salts via 24-hydroxycholesterol
REACT_11048Synthesis of bile acids and bile salts via 27-hydroxycholesterol
REACT_11041Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol