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MT000179

UniProt Annotations

Entry Information

Gene Name	2,4-dienoyl CoA reductase 1, mitochondrial
Protein Entry	DECR_HUMAN
UniProt ID	Q16698
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16698-1; Sequence=Displayed; Name=2; IsoId=Q16698-2; Sequence=VSP_056388; Note=No experimental confirmation available.;
Biophysicochemical Properties	Kinetic parameters: KM=7.7 uM for NADPH {ECO:0000269\|PubMed:15531764}; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA {ECO:0000269\|PubMed:15531764}; Vmax=30.3 umol/min/mg enzyme {ECO:0000269\|PubMed:15531764};
Catalytic Activity	Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH. {ECO:0000269\|PubMed:15531764}.
Function	Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion.
Subunit	Homotetramer. {ECO:0000269\|PubMed:15531764}.
Tissue Specificity	Heart = liver = pancreas > kidney >> skeletal muscle = lung. {ECO:0000269\|PubMed:7818482}.