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MT000181

Record overview

MITO IDMT000181
Gene ID1716
SpeciesHomo sapiens (Human)
Gene Namedeoxyguanosine kinase
Gene SymbolDGUOK
SynonymsdGK; MTDPS3;
Alternate namesdeoxyguanosine kinase, mitochondrial;
Chromosome2
Map Location2p13
EC Number2.7.1.113
SummaryIn mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DGUOK

Proteins

deoxyguanosine kinase, mitochondrial isoform a precursor
Refseq ID:NP_550438
Protein GI:18426967
UniProt ID:Q16854
mRNA ID:NM_080916
Length:277
RefSeq Status:
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMY
REPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASPQVCL
KRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
 
N
transit_peptide: 1..39
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q16854.2)
calculated_mol_wt: 4113
peptide sequence: 
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPR

transit_peptide: 1..39
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q16854.2)
calculated_mol_wt: 4113
peptide sequence: 
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPR

mat_peptide: 40..277
product: Deoxyguanosine kinase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q16854.2)
calculated_mol_wt: 27961
peptide sequence: 
RLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQI
FERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHF
EALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
 
deoxyguanosine kinase, mitochondrial isoform b precursor
Refseq ID:NP_550440
Protein GI:18426971
UniProt ID:Q16854
mRNA ID:NM_080918
Length:189
RefSeq Status:
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMY
REPARWSYTFQTFSFLSRLKVQLEPFPEKLLQARKPVQIFERSVYSDRLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
 
N
transit_peptide: 1..39
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q16854.2)
calculated_mol_wt: 4113
peptide sequence: 
MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPR