MitoProteome Database

MT000182

Gene Information

Entrez Gene ID	1723
Gene Name	dihydroorotate dehydrogenase (quinone)
Gene Symbol	DHODH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0005743	TAS:Reactome	C	mitochondrial inner membrane
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0004152	TAS:Reactome	F	dihydroorotate dehydrogenase activity
GO:0004158	IEA:Ensembl	F	dihydroorotate oxidase activity
GO:0008144	IEA:Ensembl	F	drug binding
GO:0010181	IEA:Ensembl	F	FMN binding
GO:0048039	IEA:Ensembl	F	ubiquinone binding
GO:0006207	IEA:Ensembl	P	'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205	IEA:UniProtKB-UniPathway	P	'de novo' UMP biosynthetic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0007595	IEA:Ensembl	P	lactation
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0006206	TAS:Reactome	P	pyrimidine nucleobase metabolic process
GO:0046134	TAS:Reactome	P	pyrimidine nucleoside biosynthetic process
GO:0090140	IEA:Ensembl	P	regulation of mitochondrial fission
GO:0031000	IEA:Ensembl	P	response to caffeine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0044281	TAS:Reactome	P	small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa01100	Metabolic pathways
hsa00240	Pyrimidine metabolism
ko00240	Pyrimidine metabolism
hsa_M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP

REACTOME Pathway Links