MitoProteome Database

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MT000186

Gene Information

Entrez Gene ID1738
Gene Namedihydrolipoamide dehydrogenase
Gene SymbolDLD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0043159 IEA:EnsemblCacrosomal matrix
GO:0005929 IEA:EnsemblCcilium
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:UniProtCmitochondrion
GO:0005634 IDA:HPACnucleus
GO:0004148 TAS:ProtIncFdihydrolipoyl dehydrogenase activity
GO:0050660 IEA:InterProFflavin adenine dinucleotide binding
GO:0009083 TAS:ReactomePbranched-chain amino acid catabolic process
GO:0045454 IEA:InterProPcell redox homeostasis
GO:0044237 TAS:ReactomePcellular metabolic process
GO:0034641 TAS:ReactomePcellular nitrogen compound metabolic process
GO:0007369 IEA:EnsemblPgastrulation
GO:0006554 TAS:ReactomePlysine catabolic process
GO:0006120 IEA:EnsemblPmitochondrial electron transport, NADH to ubiquinone
GO:0006508 IEA:EnsemblPproteolysis
GO:0006090 TAS:ReactomePpyruvate metabolic process
GO:0010510 TAS:ReactomePregulation of acetyl-CoA biosynthetic process from pyruvate
GO:0042391 IEA:EnsemblPregulation of membrane potential
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0048240 IEA:EnsemblPsperm capacitation
GO:0006099 TAS:ReactomePtricarboxylic acid cycle
KEGG Pathway Links
KEGG Pathway IDDescription
hsa01200Carbon metabolism
ko01200Carbon metabolism
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa00020Citrate cycle (TCA cycle)
ko00020Citrate cycle (TCA cycle)
hsa_M00009Citrate cycle (TCA cycle, Krebs cycle)
M00009Citrate cycle (TCA cycle, Krebs cycle)
hsa00260Glycine, serine and threonine metabolism
ko00260Glycine, serine and threonine metabolism
hsa00010Glycolysis / Gluconeogenesis
ko00010Glycolysis / Gluconeogenesis
hsa_M00036Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00036Leucine degradation, leucine => acetoacetate + acetyl-CoA
hsa01100Metabolic pathways
hsa00620Pyruvate metabolism
ko00620Pyruvate metabolism
hsa_M00307Pyruvate oxidation, pyruvate => acetyl-CoA
M00307Pyruvate oxidation, pyruvate => acetyl-CoA
hsa00280Valine, leucine and isoleucine degradation
ko00280Valine, leucine and isoleucine degradation
BIOCYC Pathway Links
BIOCYC Pathway IDDescription
PWY-51302-oxobutanoate degradation I
PWY-51302-oxobutanoate degradation I
PWY-50842-oxoglutarate decarboxylation to succinyl-CoA
PWY-50842-oxoglutarate decarboxylation to succinyl-CoA
PWY-50462-oxoisovalerate decarboxylation to isobutanoyl-CoA
PWY-50462-oxoisovalerate decarboxylation to isobutanoyl-CoA
GLYCINE-SYN2-PWYglycine biosynthesis II
GLYCLEAV-PWYglycine cleavage
GLYCLEAV-PWYglycine cleavage
ILEUDEG-PWYisoleucine degradation I
ILEUDEG-PWYisoleucine degradation I
PYRUVDEHYD-PWYpyruvate decarboxylation to acetyl CoA
PYRUVDEHYD-PWYpyruvate decarboxylation to acetyl CoA
PWY-5328superpathway of methionine degradation
PWY-5328superpathway of methionine salvage and degradation
PWY-5690TCA cycle II (eukaryotic)
PWY66-398TCA cycle VIII (metazoan)
VALDEG-PWYvaline degradation I
VALDEG-PWYvaline degradation I
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_197Branched-chain amino acid catabolism
REACT_1785Citric acid cycle (TCA cycle)
REACT_1298Lysine catabolism
REACT_111217Metabolism
REACT_13Metabolism of amino acids and derivatives
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_111083The citric acid (TCA) cycle and respiratory electron transport