MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT000191

UniProt Annotations

Entry Information

Gene Name	dihydropyrimidinase-like 2
Protein Entry	DPYL2_HUMAN
UniProt ID	Q16555
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16555-1; Sequence=Displayed; Name=2; IsoId=Q16555-2; Sequence=VSP_044941; Note=No experimental confirmation available.;
Caution	Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. {ECO:0000305}.
Function	Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269\|PubMed:11477421, ECO:0000269\|PubMed:15466863, ECO:0000269\|PubMed:20801876}.
Ptm	3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. {ECO:0000269\|PubMed:10757975, ECO:0000269\|PubMed:15466863, ECO:0000269\|PubMed:16964243, ECO:0000269\|PubMed:18669648, ECO:0000269\|PubMed:21406692}.
Ptm	Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. {ECO:0000250, ECO:0000269\|PubMed:10757975, ECO:0000269\|PubMed:15466863, ECO:0000269\|PubMed:16964243, ECO:0000269\|PubMed:21406692}.
Similarity	Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. {ECO:0000305}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269\|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269\|PubMed:20801876}. Membrane {ECO:0000269\|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
Subunit	Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C- terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1. {ECO:0000269\|PubMed:14685275, ECO:0000269\|PubMed:16260607, ECO:0000269\|PubMed:17250651, ECO:0000269\|PubMed:19235893, ECO:0000269\|PubMed:20801876}.
Tissue Specificity	Ubiquitous.