MitoProteome Database

MT000297

UniProt Annotations

Entry Information
Gene NameDnaJ (Hsp40) homolog, subfamily A, member 1
Protein EntryDNJA1_HUMAN
UniProt IDP31689
SpeciesHuman
Comments
Comment typeDescription
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P31689-1; Sequence=Displayed; Name=2; Synonyms=nDnaJA1; IsoId=P31689-2; Sequence=VSP_046566;
Function Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
Induction Up-regulated by heat shock. {ECO:0000269|PubMed:9192730}.
Interaction Q9GZX7:AICDA; NbExp=6; IntAct=EBI-347834, EBI-3834328;
Similarity Contains 1 CR-type zinc finger. {ECO:0000305}.
Similarity Contains 1 J domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
Subunit Identified in a complex with HSPA1B and BAX. {ECO:0000269|PubMed:14752510}.
Tissue Specificity Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:15595953}.