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MT000546

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase medium-chain family member 3
Protein Entry	ACSM3_HUMAN
UniProt ID	Q53FZ2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53FZ2-1; Sequence=Displayed; Name=2; IsoId=Q53FZ2-2; Sequence=VSP_028395, VSP_028396;
Catalytic Activity	ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Caution	It is uncertain whether Met-1 or Met-9 is the initiator. {ECO:0000305}.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function	Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAC31667.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03853.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA56369.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000250}.