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MT000638

UniProt Annotations

Entry Information

Gene Name	cold shock domain containing E1, RNA-binding
Protein Entry	CSDE1_HUMAN
UniProt ID	O75534
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=O75534-1; Sequence=Displayed; Name=2; IsoId=O75534-2; Sequence=VSP_001138; Note=No experimental confirmation available.; Name=3; IsoId=O75534-3; Sequence=VSP_045615, VSP_001138; Note=No experimental confirmation available.; Name=4; IsoId=O75534-4; Sequence=VSP_045615;
Function	RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. {ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:15314026}.
Sequence Caution	Sequence=BAA74908.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18231.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Contains 9 CSD (cold-shock) domains. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. {ECO:0000269\|PubMed:10049359, ECO:0000269\|PubMed:11051545, ECO:0000269\|PubMed:15314026, ECO:0000269\|PubMed:16356927}.