MitoProteome Database

MT000639

Record overview

MITO ID	MT000639
Gene ID	7818
Species	Homo sapiens (Human)
Gene Name	death associated protein 3
Gene Symbol	DAP3
Synonyms	DAP-3; MRPS29; MRP-S29; bMRP-10;
Alternate names	28S ribosomal protein S29, mitochondrial; S29mt; death-associated protein 3; mitochondrial 28S ribosomal protein S29; ionizing radiation resistance conferring protein;
Chromosome	1
Map Location	1q22
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Orthologs	View orthologs and multiple alignments for DAP3

Proteins

28S ribosomal protein S29, mitochondrial isoform 1

Refseq ID:	NP_387506
Protein GI:	16905526
UniProt ID:	P51398
mRNA ID:	NM_033657
Length:	398
RefSeq Status:

MMLKGITRLISRIHKLDPGRFLHMGTQARQSIAAHLDNQVPVESPRAISRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLM
VRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLN
QIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMKND
WHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL

N
transit_peptide: 1..18
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000305|PubMed:11162496}; propagated from UniProtKB/Swiss-Prot (P51398.1)
calculated_mol_wt: 2123
peptide sequence: 
MMLKGITRLISRIHKLDP

mat_peptide: 19..398
product: 28S ribosomal protein S29, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P51398.1)
calculated_mol_wt: 43462
peptide sequence: 
GRFLHMGTQARQSIAAHLDNQVPVESPRAISRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLMVRKPALELLHYLKNTSFA
YPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEK
GSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMKNDWHGGAIVSALSQTGSLFK
PRKAYLPQELLGKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL

28S ribosomal protein S29, mitochondrial isoform 1

Refseq ID:	NP_004623
Protein GI:	4758118
UniProt ID:	P51398
mRNA ID:	NM_004632
Length:	398
RefSeq Status:

28S ribosomal protein S29, mitochondrial isoform 1
Protein sequence is identical to GI:16905526 (mRNA isoform)

Refseq ID:	NP_001186778
Protein GI:	315434212
UniProt ID:	P51398
mRNA ID:	NM_001199849
Length:	398
RefSeq Status:

28S ribosomal protein S29, mitochondrial isoform 2
Protein sequence is identical to GI:16905526 (mRNA isoform)

Refseq ID:	NP_001186779
Protein GI:	315434214
UniProt ID:	P51398
mRNA ID:	NM_001199850
Length:	364
RefSeq Status:

28S ribosomal protein S29, mitochondrial isoform 3
`MMLKGITRLISRIHKLDPGRFLHMGTQARQSIAAHLDNQVPVESPRAISRTNENDPVKTFSEACLMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGK TLSLCHVIHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVR NATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGF DALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL`

Refseq ID:	NP_001186780
Protein GI:	315434216
UniProt ID:	P51398
mRNA ID:	NM_001199851
Length:	357
RefSeq Status:

`MMLKGITRLISRIHKAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHV IHFCAKQDWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVG IVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDALDPFI PILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL`