Home
MitoProteome Human Mitochondrial Protein Database
MitoProteome Database
New search
|
Record Overview
|
Ontology/Pathway Information
|
Domain Information
|
UniProt Annotations
|
Related Proteins
MT000648
UniProt Annotations
Entry Information
Gene Name
A kinase (PRKA) anchor protein 1
Protein Entry
AKAP1_HUMAN
UniProt ID
Q92667
Species
Human
Comments
Comment type
Description
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=AKAP149; IsoId=Q92667-1; Sequence=Displayed; Name=2; Synonyms=S-AKAP84; IsoId=Q92667-2; Sequence=VSP_002845, VSP_002846; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Domain
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Function
Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
Interaction
Q7Z4T9-4:MAATS1; NbExp=3; IntAct=EBI-2120060, EBI-2119735; Q99417:MYCBP; NbExp=2; IntAct=EBI-2120060, EBI-716185; P13861:PRKAR2A; NbExp=3; IntAct=EBI-2119593, EBI-2556122;
Similarity
Contains 1 KH domain. {ECO:0000255|PROSITE- ProRule:PRU00117}.
Similarity
Contains 1 Tudor domain. {ECO:0000255|PROSITE- ProRule:PRU00211}.
Subcellular Location
Mitochondrion outer membrane {ECO:0000305}.
Tissue Specificity
AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma.
MitoProteome Human Mitochondrial Protein Database
Contact us