MitoProteome Database

MT000649

Record overview

MITO ID	MT000649
Gene ID	8192
Species	Homo sapiens (Human)
Gene Name	caseinolytic mitochondrial matrix peptidase proteolytic subunit
Gene Symbol	CLPP
Synonyms	DFNB81; PRLTS3;
Alternate names	ATP-dependent Clp protease proteolytic subunit, mitochondrial; endopeptidase Clp; ATP-dependent protease ClpAP, proteolytic subunit, human; ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit; ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog; putative ATP-dependent Clp protease proteolytic subunit, mitochondrial; ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog;
Chromosome	19
Map Location	19p13.3
EC Number	3.4.21.92
Summary	The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for CLPP

Proteins

ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor

Refseq ID:	NP_006003
Protein GI:	5174419
UniProt ID:	Q16740
mRNA ID:	NM_006012
Length:	277
RefSeq Status:

`MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVI AQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMK LKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST`

N
transit_peptide: 1..56
calculated_mol_wt: 6032
peptide sequence: 
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRAL

mat_peptide: 57..277
product: ATP-dependent Clp protease proteolytic subunit, mitochondrial
calculated_mol_wt: 24166
peptide sequence: 
PLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGS
LLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEP
TLVQKEPVEAAPAAEPVPAST