MitoProteome Database

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MT000663

UniProt Annotations

Entry Information

Gene Name	delta(4)-desaturase, sphingolipid 1
Protein Entry	DEGS1_HUMAN
UniProt ID	O15121
Species	Human

Comments

Comment type	Description
Function	Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269\|PubMed:11937514}.
Interaction	P11217:PYGM; NbExp=1; IntAct=EBI-1052713, EBI-357469; P53985:SLC16A1; NbExp=1; IntAct=EBI-1052713, EBI-1054708; O15260:SURF4; NbExp=1; IntAct=EBI-1052713, EBI-1044848; Q53HC9:TSSC1; NbExp=1; IntAct=EBI-1052713, EBI-1055422;
Ptm	Myristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels. {ECO:0000269\|PubMed:19647031}.
Similarity	Belongs to the fatty acid desaturase family. DEGS subfamily. {ECO:0000305}.
Subcellular Location	Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity	Ubiquitous. {ECO:0000269\|PubMed:9188692}.