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MT000676

UniProt Annotations

Entry Information

Gene Name	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Protein Entry	CDS2_HUMAN
UniProt ID	O95674
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95674-1; Sequence=Displayed; Name=2; IsoId=O95674-2; Sequence=VSP_015477, VSP_015480, VSP_015482; Note=No experimental confirmation available.;
Catalytic Activity	CTP + phosphatidate = diphosphate + CDP- diacylglycerol.
Developmental Stage	No expression detected at E10.5 in the developing brain. At E12.5 expression is detected in the developing sentral nervous system and peripheral nervous system. At E17.5 high levels of expression are detected in a number of sites, including the dorsal root ganglia of the peripheral nervous system and the ganglion cell layer of the neural retina in the developing eye. At this stage expression in the brain is restricted to the ventricular zone of the telencephalon, in particular in the basal ganglia and the cerebral cortex. {ECO:0000269\|PubMed:9889000}.
Function	Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Similarity	Belongs to the CDS family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.
Tissue Specificity	Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269\|PubMed:9889000}.